At Aurigene Pharmaceutical Services, we specialize in analytical solutions that support every stage of small molecule drug development—from discovery through clinical advancement. Our services are built on a foundation of deep scientific expertise and state-of-the-art instrumentation, enabling precise isolation, purification, and characterization of complex pharmaceutical compounds.
With over 20 years of experience, our team applies advanced chromatographic and spectroscopic techniques to address critical challenges such as impurity profiling, enantioselective resolution, and permeability prediction. Whether you're working with New Chemical Entities, PROTACs, peptides, or nucleosides, we deliver tailored analytical strategies that align with global regulatory expectations and accelerate your development timelines.
Our Services
HPLC Method Development & Validation (Non-GxP)
- Development of robust, reproducible methods for APIs, raw materials, and finished products
- Utilizes HPLC/UPLC systems with PDA, MS, RI, CAD, and ELSD detectors
- Customized protocols for non-GxP environments to support early-phase development
Chiral & Achiral Separation Solutions via SFC
- Supercritical Fluid Chromatography (SFC) for rapid, solvent-efficient purification
- Complimentary compound screening using latest chiral stationary phases
- Scalable purification from milligrams to hundreds of grams
Impurity Isolation & Characterization
- Prep HPLC for isolating unknown impurities
- Structural elucidation using NMR (¹H, ¹³C, DEPT, COSY, HMBC, HSQC), HRMS, IR, LCMS/MS
NMR Spectroscopy & Structural Elucidation
- 400 MHz instrumentation with multi-nuclear capabilities (¹H, ¹³C, ¹¹B, ¹⁹F, ³¹P)
- Advanced 1D and 2D techniques: COSY, TOCSY, HSQC, HMBC
- Quantitative NMR analysis
EPSA (Experimental Polar Surface Area) Analysis
- SFC-based polarity screening for permeability prediction
- Ideal for bRo5 compounds including PROTACs, macrocycles, and cyclic peptides
- Supports early-stage drug design and bioavailability assessment
IAM (Immobilized Artificial Membrane) Chromatography
- Simulates drug-membrane interactions for lipophilicity and permeability profiling
- High-throughput screening capability with cost-effective performance
- Valuable alternative to traditional Log D methods
Specialty Capabilities
- Mass Directed Purification (MDP) for targeted compound isolation
- Supercritical Fluid Chromatography (SFC) for both chiral and achira mixture separations
- Advanced impurity management aligned with ICH thresholds (e.g., >0.1% characterization requirement)
- Expertise in complex molecules including small peptides, nucleosides, PROTACs, and cyclic compounds
- Regulatory foresight to mitigate delays in API scale-up and ensure patient safety
- Multi-technique structural elucidation combining NMR, HRMS, IR, and LCMS/MS for complete molecular insight
Why Choose Aurigene?
Decades of experience in analytical chemistry and pharmaceutical development
Access to cutting-edge instrumentation and purification platforms
Rapid turnaround with flexible scale-up from milligrams to grams
Efficient project management and transparent communication
Supporting drug development programs across continents with precision and reliability
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Hyderabad R and D Center
Bangalore R and D Center
Pharmaceutical Analytical Services
Connect with our scientific experts for your drug discovery, development, and manufacturing needs
We understand that clear communication is essential to successful collaborations, and that's why we have a dedicated team that is always ready to help you. Whether you have questions about our services, want to discuss a potential partnership, or simply want to learn more about our company, we're here to help.
Our team of experts is dedicated to providing personalised solutions tailored to your unique needs. So, please don't hesitate to reach out to us. We look forward to hearing from you and helping you achieve your business goals.
Learning Resources
JANUARY 04, 2021
Role of Peptide Synthesis Based Drugs
Amino acids, peptides and proteins play multiple roles in the normal functioning of the body.Group of amino acids between 2 to 50 are called peptides. They often act as hormones and play diverse roles in the normal biological processes in the human body such as metabolism, intercellular signaling and neurotransmission.Peptide synthesis based drug have a high pote...
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Accelerating Drug Discovery Through Innovative Partnerships
Genomics plays a vital role in identifying which gene is associated with a specific disease. A gene called CNOT1 is for example known for it's effect on brain development and for impairing memory and learning. Despite the great promise genomics provides in understanding the disease, genes are not the best drug targets....
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Technology meets sustainability - How a complex API development process goes green
We are always looking for ways to enhance the sustainability of our products and services. Our team successfully developed a scalable manufacturing process for the API product of one of our Biotech clients using eco-friendly manufacturing technologies. Read the case study to learn more....
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August 28, 2020
An efficient and convenient protocol for the synthesis of tetracyclic isoindolo[1,2-a]quinazoline derivatives
A convenient and one-pot synthesis of tetracyclic isoindolo [1,2-a]quinazoline derivatives via Lewis acid mediated sequential C–N bond formation reactions is reported. This protocol provides a simple and rapid strategy for the synthesis of 12-benzylidene-10,12-dihydroisoindolo[1,2-b]quinazoline derivatives. However, a variety of tetracyclo indole fused quinazol...
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April 21, 2026
H2SO4-SiO2 catalyzed synthesis, in silico and in vitro evaluation of quinazoline-based fused tetracyclic derivatives as new inhibitors of PDE4B
The 6,6a-dihydro-5H-isoquinolino[2,3-a]quinazoline-5,7,12-trione (DIQT) derivatives (that belong to the quinazoline-based fused tetracyclic class of compounds) though known in the literature, their biological properties have not been explored previously. In the current study, we have explored the phosphodiesterase 4B (PDE4B, an important target for the identifica...
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January 31, 2025
Development and assessment of a Bcs class II - SGLT2 (Sodium Glucose Cotransporter 2) inhibitor drug in the form of solid lipid Nanoparticles by selecting different lipids, co-surfactants, and manufacturing techniques
Drug Delivery System (DDS) has been used successfully in the past few decades to cure illnesses and enhance health because of its improved systemic circulation and ability to regulate the drug's pharmacological action. As pharmacology and pharmacokinetics advanced, the idea of controlled release emerged, demonstrating the significance of drug release in assessing...
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January 31, 2025
Development of novel paullone-based PROTACs as anticancer agents
Proteolysis-targeting chimera (PROTACs) represents a promising modality that has gained significant attention for cancer treatment. Using PROTAC technology, we synthesized novel structurally modified paullone-based PROTACs using Cereblon (CRBN) and Von Hippel–Lindau (VHL) E3 ligands....
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Frequently asked questions
How are analytical workflows optimized for high-throughput screening environments?
Automation, rapid chromatographic methods, and multiplexed detection systems are used to increase throughput. Aurigene integrates automated analytical platforms to support fast-paced screening and lead optimization cycles.
How is analytical data quality ensured across large discovery datasets?
Data quality is maintained through validation checks, calibration standards, and automated data processing pipelines. Aurigene ensures consistency by integrating QA practices into high-throughput analytical workflows.
How does analytical chemistry contribute to reducing attrition in drug discovery?
Accurate analytical data ensures that only well-characterized compounds progress through development. Aurigene leverages its analytical expertise to identify risks early, reducing downstream failures and improving success rates.
How is analytical chemistry integrated with medicinal chemistry during SAR studies?
Analytical data confirms compound identity and purity for each SAR iteration, ensuring reliable biological activity data. Rapid analytical feedback enables faster design–make–test cycles.
How are analytical errors minimized in high-throughput environments?
Analytical errors are minimized through automation, standardized workflows, and system checks that ensure consistent data generation across large datasets. Aurigene applies automated platforms with built-in quality controls to maintain accuracy and reliability in high-throughput discovery workflows.
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