• search
Country
CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Carbohydrate Development and Manufacturing Services

Carbohydrate Development and Manufacturing Services

Aurigene offers innovative solutions for custom synthesis, analysis and GMP manufacturing of complex multi-step carbohydrates.

While carbohydrates have the potential to develop various therapeutic drugs, there is an inherent structural complexity in developing these molecules. At Aurigene, we have a rich track record of having worked on all classes of carbohydrates such as Monosaccharides, Polysaccharides, Iminosugars, Carbocyclic sugars, Nucleosides, Locked nucleic acids (LNA), Glycopeptides, and Thioglycosides. We have capabilities across complex multi-step carbohydrates involving linear and convergent synthesis, Selective protection and deprotection, control of selectivity in moisture-sensitive glycosylation, handling of triflates, azide transfer, and oxidations. We also have hands-on experience in the use of glycosyl donors like SMethyl and STolyl and have capabilities in downstream purification and isolation involving water-soluble intermediates.

Speak to our experts

Lab Infrastructure

We have lab-scale operations of up to 100 grams per batch. Our purification infrastructure at the lab scale includes

  • 1 Akta explorer ion exchange chromatography
  • 1 Aktaprime plus ion exchange chromatography
  • Gel permeation chromatography columns

Isolation techniques

We have distillation, precipitation, and lyophilization techniques for isolation. For lyophilization, we have Virtis Programmable Tray 3 L Capacity & Virtis Benchtop 4 L Capacity.

Manufacturing Infrastructure

Carbohydrates are manufactured in Hyderabad (CTO-2) and Visakhapatnam (CTO-6 and CTO-SEZ)

  • Telescoping operations at a commercial scale
  • Operation efficiency to remove chromatographic separation and use of simple techniques to limit impurities such as solubility and solvent-based extractions
  • C-18 purification (up to 2 Kg of the crude compound)
  • Gel Permeation Chromatography (GPC) purification
  • Size exclusion chromatography
  • Strong Anion Exchange (SAX) purification
  • Water For Injection (WFI)

Analytical Capability

We have advanced analytical tools for the characterization of carbohydrates

Less or no chromophore substrates

  • Evaporative Light Scattering Detection
  • Refractive Index (RI)
  • CAD detector
  • Low wavelength UV detection

Highly polar substrates

  • Range of specialized carbohydrate columns
  • Ion exchange chromatography for polar moieties

Analysis of counter ions e.g., Na+, K+, SO42- SO32-

  • Ion chromatography by conductivity detection

Characterization of API and its impurities by

  • LC-QqQ-MS, LC-Tof instruments for characterization
  • 600 MHz Nuclear Magnetic Resonance Spectrometry

Why Aurigene Pharmaceutical Services?

Experience of 20+ years

Comprehensive infrastructure at lab and plant for a full suite of services

State-of-the-art PAT tools and QbD approach to support optimization

Phase-appropriate development approach

Virtual Tour

 

Contact Us

Country
CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
resourceMainImage

JUNE 28, 2022

Neoantigen Specific T cells For Cancer Immunotherapy

Neoantigen specific T cells for cellular cancer immunotherapy An effective anti-tumor immune response in human is marked by presence of T cells reactive against neoantigens. Neoantigens are HLA-bound unique peptides arise from tumor-specific somatic mutations. Neoantigens are highly immunogenic because they are not present in normal tissues and hence...

Read More
resourceMainImage

Building successful long-term partnerships with CDMOs from early drug discovery through commercialization

Building successful long-term partnerships with CDMOs from early drug discovery through commercialization Maximizing efficiency in drug research, development, and manufacturing is crucial for turning new innovations into therapeutic and financial benefits. Over the past couple of decades, pharmaceutical companies have increasingly turned to contr...

Read More
resourceMainImage

Technology meets sustainability - How a complex API development process goes green

We are always looking for ways to enhance the sustainability of our products and services. Our team successfully developed a scalable manufacturing process for the API product of one of our Biotech clients using eco-friendly manufacturing technologies. Read the case study to learn more. ...

Read More

Alternate end-game strategies towards Nirmatrelvir synthesis: Defining a continuous flow process for the preparation of an anti-COVID drug

2023

Scalable alternate end-game strategies for the synthesis of the anti-COVID drug molecule Nirmatrelvir (1,PF-07321332) have been described. The first involves a direct synthesis of 1 via amidation of the carboxylic acid 7 (suitably activated as a mixed anhydride with either pivaloyl chloride or T3P) with the ...

Read More
View All
×

You are about to leave Aurigene Pharmaceutical Services and affiliates website. Aurigene Pharmaceutical Services assumes no responsibility for the information presented on the external website or any further links from such sites. These links are presented to you only as a convenience, and the inclusion of any link does not imply endorsement by Aurigene Pharmaceutical Services.

If you wish to continue to this external website, click Proceed.

ProceedBack