Successful antibody discovery starts with high-quality antigen and strategic immunization. At Aurigene, we specialize in designing and preparing custom immunogens and applying tailored immunization strategies across multiple animal species to elicit robust and specific immune responses.
Capabilities
Antigen/Immunogen Design & Preparation
- Formats: Protein/fusion-protein, peptide conjugates, nucleic acids (pDNA/mRNA), viral vectors, VLPs, nano-discs, membrane preparations, and tissue samples
- QC Tools: SDS-PAGE, WB, SEC-HPLC, LC-MS, ELISA, SPR, flow cytometry
Custom Screening Reagents
- Recombinant cell lines (KI/KO), protein conjugates, reference mAbs, and tissue samples
- QC using advanced analytical techniques
Animal Models
- Mice, rats, rabbits, humanized and transgenic rodents
- Neonatal tolerization for epitope specificity and minimizing immunogenic responses
- Expertise in breaking immune tolerance (e.g., mouse-in-mouse)
Immunization Strategies
- Proprietary immunization protocols for high affinity (pM) antibody discovery
- Platforms: Protein/Fusion proteins, mRNA-LNPs, pDNA electroporation, viral vectors, whole cells, nano-discs, membrane preps
- Adjuvant combinations tailored per target
- Anti-idiotypic antibody generation for PK/ADA assay support
Why Aurigene Antigen Preparation & Immunization Services?
Experties in high-affinity (pM) antibody discovery
Full spectrum of antigen types and QC workflows
Expertise in advanced and conventional animal models
Custom project designs to improve response quality
Support for downstream functional assay development
Virtual Tour
Hyderabad R and D Center
Bangalore R and D Center
Connect with our scientific experts for your drug discovery, development, and manufacturing needs
We understand that clear communication is essential to successful collaborations, and that's why we have a dedicated team that is always ready to help you. Whether you have questions about our services, want to discuss a potential partnership, or simply want to learn more about our company, we're here to help.
Our team of experts is dedicated to providing personalised solutions tailored to your unique needs. So, please don't hesitate to reach out to us. We look forward to hearing from you and helping you achieve your business goals.
Learning Resources
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Development and assessment of a Bcs class II - SGLT2 (Sodium Glucose Cotransporter 2) inhibitor drug in the form of solid lipid Nanoparticles by selecting different lipids, co-surfactants, and manufacturing techniques
Drug Delivery System (DDS) has been used successfully in the past few decades to cure illnesses and enhance health because of its improved systemic circulation and ability to regulate the drug's pharmacological action. As pharmacology and pharmacokinetics advanced, the idea of controlled release emerged, demonstrating the significance of drug release in assessing...
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Development of novel paullone-based PROTACs as anticancer agents
Proteolysis-targeting chimera (PROTACs) represents a promising modality that has gained significant attention for cancer treatment. Using PROTAC technology, we synthesized novel structurally modified paullone-based PROTACs using Cereblon (CRBN) and Von Hippel–Lindau (VHL) E3 ligands....
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Development and verification of RP-HPLC method for the quantitative determination of Decitabine in tablet dosage formulation
Decitabine is an anti-cancer chemotherapy drug. This article describes method development and method verification of Assay of Decitabine in tablet formulation. A new, precise, rapid, accurate RP-HPLC method has been developed for the estimation of Decitabine in pharmaceutical tablets dosage form. After optimization the good chromatographic separation was achieved...
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