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In vivo Pharmacology Studies and Services

In vivo Pharmacology Studies and Services

We are an efficient partner for in vivo pharmacology services with our experience in multiple therapeutic areas, target specific models, and a team of highly competent scientists.

In vivo pharmacology is essential to evaluate the complex physiological effects of a drug in the living organism. In vivo pharmacology studies are offered by Aurigene to assess the effectiveness and early toxicity of small compounds and large molecules. Our in vivo pharmacology services are backed by an AAALAC accredited vivarium.

Our expanding disease models include pain management, inflammation & auto immune diseases, metabolic disorders, oncology etc.

Speak to our experts

Few therapeutic areas where we offer pharmacology discovery services are highlighted below:

Pain Models and Measurements

Aurigene has successfully collaborated with the world’s top pharmaceutical companies for pain drug discovery. Our expertise and experience allow us to offer an extensive portfolio of services supporting drug discovery and development. We match the industry’s needs in the domains of:

  • Acute and chronic inflammatory pain
  • Visceral pain
  • Arthritic pain
  • Neuropathic pain
Type​ Animal Model Species/ strain​ Validation standard​
Acute Models Acetic acid induced writhing Male Swiss albino mice​ Indomethacin/Tramadol​
Carrageenan-induced mechanical hyperalgesia ​ Male Wistar rat​ Celecoxib​
Complete Freund’s adjuvant (CFA) induced thermal hyperalgesia Male Sprague Dawley rat​ Indomethacin​
Arthritic Pain​ CFA-induced mono arthritis pain​ Male Sprague Dawley rat​ Naproxen​
Monoidoacetate-induced osteoarthritis pai​ Male Sprague Dawley rat ​ Diclofenac​
Neuropathic Pain Partial sciatic nerve ligation​ Male Wistar rat​ Gabapentin ​

Inflammation and Auto-immune Disorders

Our team of experts have developed in vivo models for autoimmune and inflammatory diseases. We offer inflammation animal models associated with:

  • Neurological diseases
  • Respiratory diseases
  • Arthritis
  • Skin diseases
  • Gastrointestinal diseases and
Type​ Animal Model Species/ strain​ Validation standard​
Acute Models LPS-induced systemic inflammation (Plasma TNF-α) Female wistar rat/ Male BALB/c mice​ Roflumilast / Theophylline​
LPS-induced systemic inflammation (Plasma IL-17 )​ Male C57BL/6 mice​​ Digoxin​
LPS-induced paw edema​ Female wistar rat​ Nimesulide
Carrageenan-induced paw edema​ Male wistar rat​​ Celecoxib​
Acute Arthus reaction​ Female C57BL mice​ Kinase inhibitor​
The SCF-induced systemic histamine release model​ Female BALB/c mice​ Anti C-KIT antibody
Mouse passive cutaneous anaphylaxis model​ Female C57BL/6 mice​ Dexamethasone
TNF + Zvad induced hypothermia​ Female C57BL mice Kinase inhibitor
Arthritis Collagen-Induced Arthritis (Prophylactic)​ Female Lewis rat​ Leflunomide​
Collagen-Induced Arthritis (Therapeutic)​​ Female Lewis rat​ Enbrel, Dexamethasone​​
Adjuvant-Induced Arthritis (Prophylactic)​​​ Female Lewis rat​ Celecoxib​
Medial Meniscus Induced Tear Osteo Arthritic model​ Female Lewis rat​ Celecoxib​​​
Dermatitis & Psoriasis DNFB-induced contact dermatitis ​​ Female CD1 mice​ Leflunomide​ ​
Oxazolone-induced contact dermatitis​ Male SD rat​ Dexamethasone
Imiquimod-induced psoriasis model​​ Female Balb/c mice​ Dexamethasone /Anti mouse IL-17 anti body
IL-23-induced dermatitis model​ Female Balb/c mice​​ Tofacitinib/​
Colitis Dextran Sulphate Sodium induced colitis​ C57BL/6 mice​​​ cyclosporin​​
Trinitrobezene sulphonic acid-induced colitis ​ Female wistar rat/ BALB/c mice​ Dexamethasone
Fibrosis Unilateral ureteral obstruction model​ Male C57BL/6 mice Necrostatin-1​
Acne​ Hamster ear sebaceous gland model​ Female Hamsters​ spironolactone​
Asthma​ Ovalbumin/LPS induced neutrophilic asthma model​ Male C57BL/6 mice​ Digoxin​
MS​ MOG-induced EAE model in C57BL/6​ Female C57BL/6 mice​ Copaxone
​

Metabolic Disorders (Diabetes, Obesity and Atherosclerosis)

The team has vast experience in conducting customized metabolic disorder animal models.

Type​ Strain-Species Activity/test Model​​ Validating/Standards​​
MD​ (Diabetes and Obesity) Mice and rats​ OGTT, IPGTT, IVLTT, and Euglycemic clamp study​​ Pioglitazone/Exenatide​
Swiss albino mice / Wistar rats/CD1 mice​​ Acute food intake modulating activity ​ Rimonabant/ PYY 3-36/Liraglutide
CD1 mice​ 3 days of administration of food intake and body weight lowering activity​ PYY 3-36​
db/db mice​ Blood glucose lowering and anti-dyslipidemic activity Pioglitazone/ liraglutide
Zucker fa/fa rats Anti-dyslipidemic activity and insulin-sensitizing activity​ Fenofibrate/Pioglitazone​
ob/ob mice​ Body weight lowering and insulin-sensitizing activity​​ Metformin/Pioglitazone
C57BL/6 - DIO mice Body weight lowering activity​ Rimonabant/PYY 3-36
CV (Atherosclerosis) LDLr -/-Mic Anti-atherosclerotic activity​ Fenofibrate​
Swiss albino mice Lipid-lowering activity Fenofibrate ​​
High-fat-fed Sprague Dawley rats Acute lipid (TC, TG) lowering activity​ Fenofibrate
Golden Syrian Hamster HDL elevating activity​ Torcetrapib ​
​

Oncology Animal Model

Aurigene has significant experience in oncology drug discovery. We offer a large collection of tumor models for small and large molecule drug discovery.

Cancer type ​ Cell line​ Mice ​​​ Model type ​​
Lung cancer, NSCLC A549, Known to be KRAS mutant and EGFR wild type ​ Ncr nude mice​​ Xenograft, subcutaneous​
Multiple Myeloma ​ H929​​ NOD SCID mice ​ Xenograft, subcutaneous​
Breast cancer​ MCF-7 cells are ER+, progesterone receptor-positive, and HER2 negative.​​ Ncr nude mice ​​​ Xenograft, subcutaneous​
Prostate cancer​ 22RV1, cell line has been derived from a human prostatic carcinoma xenograft, CWR22R Ncr nude mice Xenograft, subcutaneous​
Colon cancer​ COLO 205 non metastatic ​​ Ncr nude mice​​ Xenograft, subcutaneous​
Leukemia​ MV-4-11, human biphenotypic B myelomonocytic leukemia​​​ Ncr nude mice Xenograft, subcutaneous​​
Colon cancer​ CT26​​ BALB/c mice Syngeneic, subcutaneous​
Established model ​
Ovarian cancer​ SKOV-03​​ Ncr nude mice Xenograft, subcutaneous
Established model​
Acute myeloid leukemia​ MOLM-13​​ NOD SCID mice Xenograft, subcutaneous
Established model​
​

Miscellaneous models

  • Mouse/ rat whole blood and splenocyte assays with different stimulants (LPS, NECA) and evaluation of cytokines and biomarkers using flow cytometer.
  • Oxidative stress markers evaluation in rats administered with repeat intravenous Iron formulation.
  • Evaluation of test compounds potential in modulating serum Iron and hepcidin expression modulation in restricted iron diet fed rats.
  • Evaluation of test compounds potential in muscle regeneration in thermal injury mice model.
  • Anti-acne potential evaluation of test compounds in hamsters ear sebaceous gland model.
  • Evaluation of test compounds efficacy in mice post-operative ileus model.
  • Evaluation of test compounds efficacy in gastric emptying and intestinal motility in mice model

Why Aurigene Pharmaceutical Services?

Experience in submissions to the US FDA and DCGI

Highly qualified and experienced scientists

Capacity to handle more than 600 rodents at a given time

AAALAC accredited vivarium

Other Services

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