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Discovery Biology Services Discovery Biology Services

Discovery Biology Services

Standalone and integrated solutions in discovery biology across drug discovery cycle.

At Aurigene Pharmaceutical Services, we offer a wide range of integrated discovery biology services to meet your drug discovery needs. We offer end-to-end services including in vitro biology, ADME & DMPK studies, Toxicology, in vivo pharmacology and microbiology testing.             

We provide integrated and standalone drug discovery services ranging from target identification to candidate nomination and further extension up to development services. Our best-in-class discovery biology services are supported by AAALAC accredited vivarium, BSL-2 compliant labs, in vivo facilities, GLP and other regulatory bodies accredited toxicology labs. Our discovery biology team offers a blend of scientific skills and pharmaceutical industry expertise with a proven track record of complex problem-solving capabilities. Biologists holding Masters, PhDs, and Postdocs are trained to undertake the most demanding drug discovery biology projects.             

During the past two decades, the team in collaboration with our clients has been able to apply differentiated solutions to each aspect of drug discovery research, which has resulted in the discovery of many clinical candidates. Numerous research publications and feedback from clients are a testimony of our success.

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In vitro Biology

Our team provides a wide range of services in biochemical assays, mechanistic assays, functional assays, immunological assays and various customized assays.

Drug Metabolism and Pharmacokinetics (DMPK)

We provide precise data and insightful analysis of a drug's absorption, distribution, metabolism and excretion (ADME) properties. These insights help the clients to shortlist compounds with a high likelihood of success in later stages of drug development. DMPK tests include:

  • Physicochemical parameters
  • Metabolism studies
  • Permeability
  • Distribution
  • Drug-drug interactions
  • Pharmacokinetics
  • Bioanalysis

In vivo Pharmacology Studies

Our in vivo pharmacology team has expertise across multiple therapeutic areas. The team is supported by an AAALAC accredited, GLP-certified vivarium and experienced scientists who can set up diverse efficacy models as per program or client needs. We offer target engagement and efficacy models for:

  • Oncology and immuno-oncology
  • Metabolic disorders
  • Inflammation
  • Pain
  • Acute inflammation
  • Auto-immune disorders
  • Syngeneic tumor
  • Muscle regeneration
  • Skin disorders

These are validated with reference compounds and supported by histopathology and biomarker analysis.

Pharmaceutical Microbiology Testing

Our pharmaceutical microbiology testing department has a BSL-2 compliant lab and a dedicated in vivo facility for bacterial and fungal infection murine disease models. Our team has vast experience in anti-infective drug discovery biology projects. The team has worked on several collaboration projects with innovator pharma companies to discover antibacterial and antifungal agents. We have also established in-vitro time-kill kinetics bioequivalence assays of generic products for regulatory submission.


We offer a full range of exploratory and GLP toxicology studies supported by clinical and anatomic pathology services, formulation analysis, toxicokinetic analysis and interpretation and reporting. General toxicology studies range from single-dose and repeat dose toxicology studies, genetic toxicology and IND and NDA enabling safety toxicology packages. We have a track record of successfully filing INDs using the in-house data with US FDA, MHRA, EMA, DCGI and ANDAs.

Why Aurigene Pharmaceutical Services?

Expert team of scientists

65+ IDD projects delivered

State-of-the-art facilities

US FDA inspected labs with zero 483 observations

AAALAC accredited animal house

NGCMA accreditation

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“Bathtub Chemistry” - Necessity and Aspects of Process Research

“Bathtub Chemistry” - Necessity and Aspects of Process Research

Medicine is an essential part of our life. Since ancient time human civilization has been tirelessly engaged to understand the cause and effect of a disease. Sometimes they win and many times they lose. But the story of their curiosity and enthusiasm is a never damping process. On the contrary it increases day by day, year after year.Drug discovery is a vast and ...

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Accelerating Drug Discovery Through Innovative Partnerships

Genomics plays a vital role in identifying which gene is associated with a specific disease. A gene called CNOT1 is for example known for it's effect on brain development and for impairing memory and learning. Despite the great promise genomics provides in understanding the disease, genes are not the best drug targets....

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Discovery, Development and Manufacturing Services

Aurigene Pharmaceutical Services is a leading contract research, development and manufacturing organization which provides range of services to enable your IND/NDA filing ...

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Solid dispersion development to enhance solubility and oral bioavailability for rodent toxicology studies

Background: Develop oral liquid dosage form of an IND candidate (small molecule) suitable for chronic toxicology studies in rats. Must meet required systemic exposure and shall be dose proportional. Developed vehicle or used excipients shall be safe for chronic preclinical toxicology studies. Challenges: Low oral bioavailability Practically insoluble in bio relev...

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Revisiting the reaction of b-chloroacroleins with 2-aminophenol: a new observation


The reaction of b-chloroacrolein with 1 equiv of 2-aminophenol in DMF proceeds smoothly to afford 11-hydroxy derivative of chromenoquinoline in good yield. This single pot method allows for a rapid access to a variety of chromenoquinolines or oxepinoquinolines depending on the nature of b-chloroacrolein used. The structures were established by spectroscopic data ...

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