At Aurigene Pharmaceutical Services, we offer a wide range of integrated discovery biology services to meet your drug discovery needs. We offer end-to-end services including in vitro biology, ADME & DMPK studies, Toxicology, in vivo pharmacology and microbiology testing.
We provide integrated and standalone drug discovery services ranging from target identification to candidate nomination and further extension up to development services. Our best-in-class discovery biology services are supported by AAALAC accredited vivarium, BSL-2 compliant labs, in vivo facilities, GLP and other regulatory bodies accredited toxicology labs. Our discovery biology team offers a blend of scientific skills and pharmaceutical industry expertise with a proven track record of complex problem-solving capabilities. Biologists holding Masters, PhDs, and Postdocs are trained to undertake the most demanding drug discovery biology projects.
During the past two decades, the team in collaboration with our clients has been able to apply differentiated solutions to each aspect of drug discovery research, which has resulted in the discovery of many clinical candidates. Numerous research publications and feedback from clients are a testimony of our success.
In vitro Biology
Our team provides a wide range of services in biochemical assays, mechanistic assays, functional assays, immunological assays and various customized assays.
Drug Metabolism and Pharmacokinetics (DMPK)
We provide precise data and insightful analysis of a drug's absorption, distribution, metabolism and excretion (ADME) properties. These insights help the clients to shortlist compounds with a high likelihood of success in later stages of drug development. DMPK tests include:
- Physicochemical parameters
- Metabolism studies
- Permeability
- Distribution
- Drug-drug interactions
- Pharmacokinetics
- Bioanalysis
In vivo Pharmacology Studies
Our in vivo pharmacology team has expertise across multiple therapeutic areas. The team is supported by an AAALAC accredited, GLP-certified vivarium and experienced scientists who can set up diverse efficacy models as per program or client needs. We offer target engagement and efficacy models for:
- Oncology and immuno-oncology
- Metabolic disorders
- Inflammation
- Pain
- Acute inflammation
- Auto-immune disorders
- Syngeneic tumor
- Muscle regeneration
- Skin disorders
These are validated with reference compounds and supported by histopathology and biomarker analysis.
Pharmaceutical Microbiology Testing
Our pharmaceutical microbiology testing department has a BSL-2 compliant lab and a dedicated in vivo facility for bacterial and fungal infection murine disease models. Our team has vast experience in anti-infective drug discovery biology projects. The team has worked on several collaboration projects with innovator pharma companies to discover antibacterial and antifungal agents. We have also established in-vitro time-kill kinetics bioequivalence assays of generic products for regulatory submission.
Toxicology
We offer a full range of exploratory and GLP toxicology studies supported by clinical and anatomic pathology services, formulation analysis, toxicokinetic analysis and interpretation and reporting. General toxicology studies range from single-dose and repeat dose toxicology studies, genetic toxicology and IND and NDA enabling safety toxicology packages. We have a track record of successfully filing INDs using the in-house data with US FDA, MHRA, EMA, DCGI and ANDAs.
Why Aurigene Pharmaceutical Services?
Expert team of scientists
65+ IDD projects delivered
State-of-the-art facilities
US FDA inspected labs with zero 483 observations
AAALAC accredited animal house
NGCMA accreditation
Virtual Tour
Hyderabad R and D Center
Bangalore R and D Center
ADME/DMPK Services
In vivo Pharmacology
Microbiology Testing
Toxicology Studies
Contact Us
Resources
JUNE 28, 2022
Neoantigen Specific T cells For Cancer Immunotherapy
Neoantigen specific T cells for cellular cancer immunotherapy An effective anti-tumor immune response in human is marked by presence of T cells reactive against neoantigens. Neoantigens are HLA-bound unique peptides arise from tumor-specific somatic mutations. Neoantigens are highly immunogenic because they are not present in normal tissues and hence...
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Building successful long-term partnerships with CDMOs from early drug discovery through commercialization
Building successful long-term partnerships with CDMOs from early drug discovery through commercialization Maximizing efficiency in drug research, development, and manufacturing is crucial for turning new innovations into therapeutic and financial benefits. Over the past couple of decades, pharmaceutical companies have increasingly turned to contr...
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Technology meets sustainability - How a complex API development process goes green
We are always looking for ways to enhance the sustainability of our products and services. Our team successfully developed a scalable manufacturing process for the API product of one of our Biotech clients using eco-friendly manufacturing technologies. Read the case study to learn more. ...
Read MoreAlternate end-game strategies towards Nirmatrelvir synthesis: Defining a continuous flow process for the preparation of an anti-COVID drug
2023
Scalable alternate end-game strategies for the synthesis of the anti-COVID drug molecule Nirmatrelvir (1,PF-07321332) have been described. The first involves a direct synthesis of 1 via amidation of the carboxylic acid 7 (suitably activated as a mixed anhydride with either pivaloyl chloride or T3P) with the ...
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Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action.
2021
Mutations in MEK1/2 have been described as a resistance mechanism to BRAF/MEK inhibitor treatment. We report the discovery of a novel ATP-competitive MEK1/2 inhibitor with efficacy in wildtype (WT) and mutant MEK12 models. Starting from a HTS hit, we obtained selective, cellularly active ...
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Synthesis of Anti-covid Drug Nirmatrelvir Using Flow Chemistry
2021
Synthesis of the anti-covid therapeutic Nirmatrelvir by using flow chemistry to enhance efficiency of amide to nitrile conversion in a functionally and Stereochemically Embellished environment. ...
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Simple and efficient synthesis of imidazoquinoxalines and spiroquinoxalinones via pictect-spengler reaction using Wang resin, Synthetic Communications
2021
An efficient approach for the synthesis of various imidazoquinoxalines and spiroquinoxalinones has been reported from 2-(1H-imidazol-1-yl) aniline and .. ...
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