Aurigene offer diverse solutions to all your medicinal chemistry research requirements, providing the right blend of innovation, vigour, expertise and thorough knowledge of the various aspects of discovery research. With a very experienced scientific team with a 1:6 PhD to MSc ratio and a leadership team with a collective experience of >200 years, together with our experience in handling complex synthetic chemistry problems and our in-house collection of >50000 chemicals, we are ready to rapidly initiate any chemistry programs from our collaborators. We are well versed in all aspects of medicinal chemistry projects, including novel areas like carbohydrates and steroids, PROTACs and molecular glues, oligonucleotides etc.
With a combination of 600+ highly skilled scientists and a state-of-the-art infrastructure spanned over two sites at Bangalore and Hyderabad, we provide the best-in-class medicinal chemistry services to various biotech, pharmaceutical and agrochemical companies. We offer flexible business models like FFS in addition to the usual FTE mode of collaboration, in addition to offering a variety of mix and match programs like chemistry CRO programs together with DMPK or in vitro Biology programs.
Why Aurigene Medicinal Chemistry Services?
Multiple design or route options and complete design to delivery support
Capability across wide chemistry platforms
Library synthesis across various platforms
Lab facilities operating from two locations: Hyderabad and Bangalore
Service in all areas of drug discovery and development
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Medicinal Chemistry
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We understand that clear communication is essential to successful collaborations, and that's why we have a dedicated team that is always ready to help you. Whether you have questions about our services, want to discuss a potential partnership, or simply want to learn more about our company, we're here to help.
Our team of experts is dedicated to providing personalised solutions tailored to your unique needs. So, please don't hesitate to reach out to us. We look forward to hearing from you and helping you achieve your business goals.
Learning Resources
Role of Peptide Synthesis Based Drugs
Amino acids, peptides and proteins play multiple roles in the normal functioning of the body.Group of amino acids between 2 to 50 are called peptides. They often act as hormones and play diverse roles in the normal biological processes in the human body such as metabolism, intercellular signaling and neurotransmission.Peptide synthesis based drug have a high pote...
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Evolution in Pharma Industry and Demand for Integrated CDMO
The pharma industry is evolving and a demand for integrated CDMOs, which can help accelerating innovations, is part of the evolution....
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Technology meets sustainability - How a complex API development process goes green
We are always looking for ways to enhance the sustainability of our products and services. Our team successfully developed a scalable manufacturing process for the API product of one of our Biotech clients using eco-friendly manufacturing technologies. Read the case study to learn more....
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Construction of a quinoline ring via a 3-component reaction in water: crystal structure analysis and H-bonding patterns of a 2-aryl quinoline
2012
Montmorillonite K-10 mediated green and one-pot synthesis of 2-substituted quinolines has been accomplished via a 3-component reaction of aniline, aldehydes and ethyl 3,3- diethoxypropionate in the presence of air oxygen in water. The crystal structure analysis and H-bonding patterns of one compound prepared are presented. ...
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Development and assessment of a Bcs class II - SGLT2 (Sodium Glucose Cotransporter 2) inhibitor drug in the form of solid lipid Nanoparticles by selecting different lipids, co-surfactants, and manufacturing techniques
Drug Delivery System (DDS) has been used successfully in the past few decades to cure illnesses and enhance health because of its improved systemic circulation and ability to regulate the drug's pharmacological action. As pharmacology and pharmacokinetics advanced, the idea of controlled release emerged, demonstrating the significance of drug release in assessing...
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Development of novel paullone-based PROTACs as anticancer agents
Proteolysis-targeting chimera (PROTACs) represents a promising modality that has gained significant attention for cancer treatment. Using PROTAC technology, we synthesized novel structurally modified paullone-based PROTACs using Cereblon (CRBN) and Von Hippel–Lindau (VHL) E3 ligands....
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Development and verification of RP-HPLC method for the quantitative determination of Decitabine in tablet dosage formulation
Decitabine is an anti-cancer chemotherapy drug. This article describes method development and method verification of Assay of Decitabine in tablet formulation. A new, precise, rapid, accurate RP-HPLC method has been developed for the estimation of Decitabine in pharmaceutical tablets dosage form. After optimization the good chromatographic separation was achieved...
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Frequently asked questions
How does Aurigene do drug discovery services with the help of medicinal chemistry?
We offer a diverse range of end-to-end solutions to meet the drug discovery, research, and developmental needs of the pharmaceutical industry. We excel in developing the right blend of innovation, research, expertise, and knowledge within the pharmaceutical domain. Our team of skilled and professional scientists is equipped with the experience and expertise to handle complex medicinal chemistry projects using collaborative methods and advanced techniques. We have initiated multiple collaborative chemistry programs to enhance the quality and reliability of drug products and accelerate their journey to market.
With the support of technically proficient scientists and state-of-the-art infrastructure, we provide top-tier medicinal chemistry services to pharmaceutical and biotech companies globally. Our medicinal chemistry services cover various innovative areas, including carbohydrates and steroids, PROTACs, oligonucleotides, and photoredox and electroorganic reactions. We offer business models based on Fee for Service (FFS) and Full-Time Equivalent (FTE) collaboration, strengthening business partnerships
We specialize in handling air-sensitive reagents and performing complex syntheses, including azides, phosphoramidites, fluorination, cycloaddition, and cyclopropanation reactions. We also offer transition metal-mediated reactions using Cu, Ni, Pd, and Zn-catalysts.
In addition, we provide comprehensive design-to-delivery support and offer library synthesis services across a wide range of chemistry platforms. We operate from two locations in India: Hyderabad and Bangalore.
How do we ensure the quality and reliability of the medicinal chemistry services?
KW: Medicinal chemistry services
The best way to ensure the quality and reliability of medicinal chemistry services is by employing advanced technological strategies, such as artificial intelligence (AI). AI-driven tools can improve the understanding of toxicity profiles and predict the therapeutic potential of drug candidates. Moreover, the use of AI can reduce the risks associated with result accuracy while enhancing overall product safety and efficacy.
Second, standardizing methods and procedures is essential for achieving optimal results during production and manufacturing. This step is critical to ensuring the authenticity and purity of the final drug product. Method development and optimization are key stages in the broader drug development pipeline. It is important to evaluate factors that can impact the productivity, reliability, and efficiency of the overall process. Additionally, identifying and validating drug targets constitute a fundamental component of the drug discovery and development continuum. Establishing reproducible protocols and analytical methods further strengthens quality assurance across all stages.
Drug discovery and development require skilled professionals and scientists with years of experience to effectively understand and deliver results. An experienced team can carefully evaluate the pros and cons of a project, assess available resources, and ensure maximum productivity, innovation, and speed. Their ability to troubleshoot complex reactions, interpret data accurately, and adapt strategies in real time is critical to maintaining service excellence.
Assessing and validating the pharmacokinetics of a drug provides valuable insights into the biological pathways and mechanisms of action. Optimizing the pharmacokinetics is essential to ensuring the drug`s therapeutic efficacy and safety. Other critical parameters to consider include hit-to-lead generation, mathematical optimization, and API intermediate quality control and assessment protocols. By integrating these strategies, medicinal chemistry services can consistently meet high standards of performance and regulatory compliance.
What are the Medicinal Chemistry services offered by Aurigene?
KW: Medicinal chemistry, medicinal chemistry services
https://www.aurigeneservices.com/services/discovery/medicinal-chemistry-services CS
Aurigene provides quality and high-grade medicines along with end-to-end solutions for the discovery, development, and manufacturing of APIs and formulations. With skilled professionals and scientists and state-of-the-art infrastructure, they offer a wide range of best-in-class medicinal chemistry services to various companies. They provides specialized services in the synthesis and functionalization of C-, N-, O-, and S-containing heterocycles, the derivatization of fused-heterocyclic systems, and the construction of saturated heterocycles featuring C–N, C–O, and C–P bonds. They have extensive expertise in Pd-, Cu-, Zn-, and Ni-mediated C–C, C–N, and C–O bond-forming reactions, including a wide range of cross-coupling strategies. Additional capabilities include metal-mediated C–S, C–P, and C–B bond formation, C–H activation chemistry, transition metal-catalyzed carbonylation reactions, as well as advanced synthetic techniques such as ring-closing metathesis and click chemistry. Other key capabilities include the services include the handling of gaseous reagents such as H2, Cl2, O2, CO, CO2, and SO3., along with the execution of critical reactions like They also carry out ozonolysis and hydrogenation reactions, ranging from parr hydrogenation methods- to high-temperature and high-pressure autautclave-based hydrogenations.
In addition, Auriegenis actively engaged in synthesis of novel therapetic modalities, including PROTACs and ATTECs, as well as complex carbohydrate and nucleoside scaffolds. Their expertise also includes the handling of air- and moisture-sensitive reagents such as organolithiums, Grignard reagents, and organozincs, alongside the execution of cyanation reactions using inorganic cyanides.
Other services include fluorination reactions, cyclopropanation, cycloaddition reactions, and synthesis of PAL ligands. Services involving photo redox and electro organic reactions are also provided by Aurigene. They are also involved in PROTAC, ATTEC synthesis, as well as carbohydrate and nucleoside sythesis.
Aurigene’s expertise also includes the handling of air- and moisture-sensitive reagents such as organolithiums, Grignard reagents, and organozincs, alongside the execution of cyanation reactions using inorganic cyanides. The teams at Aurigene routinely perform transformations mediated by strong reducing agents like Pd-C, LAH, borane, and super-hydrides and undertake the synthesis of azides and phosphoramidites.
They are also involved in designing or diversification of scaffolds for optimal physicochemical properties (such as solubility, permeability, and ADME properties) and scaffold modification based on SAR and SPR analysis.
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