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Medicinal Chemistry Services Medicinal Chemistry Services

Medicinal Chemistry Services

We provide support to both 'chemistry only' projects and 'fully integrated' medicinal chemistry projects, together with a variety of mix and match programs which our collaborators can choose from our offerings.

Aurigene offer diverse solutions to all your medicinal chemistry research requirements, providing the right blend of innovation, vigour, expertise and thorough knowledge of the various aspects of discovery research. With a very experienced scientific team with a 1:6 PhD to MSc ratio and a leadership team with a collective experience of >200 years, together with our experience in handling complex synthetic chemistry problems and our in-house collection of >50000 chemicals, we are ready to rapidly initiate any chemistry programs from our collaborators. We are well versed in all aspects of medicinal chemistry projects, including novel areas like carbohydrates and steroids, PROTACs and molecular glues, oligonucleotides etc. 

With a combination of 600+ highly skilled scientists and a state-of-the-art infrastructure spanned over two sites at Bangalore and Hyderabad, we provide the best-in-class medicinal chemistry services to various biotech, pharmaceutical and agrochemical companies. We offer flexible business models like FFS in addition to the usual FTE mode of collaboration, in addition to offering a variety of mix and match programs like chemistry CRO programs together with DMPK or in vitro Biology programs.

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Heterocyclic Chemistry

  • Synthesis and decoration of C-, N-, O- and S-containing heterocycles
  • Synthesis and derivatizations of fused-heterocyclic systems
  • Saturated heterocyclic systems with C-N, C-O and C-P bonds

Transition Metal-mediated Reactions

  • Pd-, Cu-, Zn- and Ni-mediated C-C, C-N and C-O bond forming reactions, including all types of cross-couplings
  • Metal-mediated C-S, C-P and C-B bond-forming reactions
  • C-H activation chemistry
  • Transition metal-mediated carbonylations
  • Ring closing metathesis, click chemistry etc.

Handling of Gaseous Reagents

  • Experienced in reactions involving gases like H2 , Cl2 , O2 , CO, CO2 , SO3 etc.
  • Ozonolysis reactions
  • Hydrogenation reactions (parr, autoclave, high T & P hydrogenations etc.)

Specialized Synthetic Needs

  • Fluorinations
  • Cyclopropanations
  • Labelled and tagged compounds
  • Synthesis of PAL ligands
  • Cycloaddition reactions

Niche Fields of Interest

  • Photoredox reactions
  • Electro organic reactions
  • Decarboxylative C-C bond-forming reactions
  • PROTACs, ATTECs and molecular glues
  • Carbohydrates and Nucleosides

Difficult-to-handle and Sensitive Reagents

  • Air-sensitive reagents like organolithiums, grignard reagents, organozincs etc.
  • Cyanations using inorganic cyanides
  • Strong reducing reagents like Pd-C, LAH, borane, super-hydrides etc.
  • Synthesis of azides
  • Synthesis of phosphoramidites

Other Value-added Services

  • Design and/or diversification of scaffolds for optimal physicochemical properties (solubility, permeability, ADME properties etc.)
  • Scaffold modification and tuning based on detailed SAR and SPR analysis
  • CADD support together with medicinal chemistry for optimal target design
  • R-CDMO model, where we support all stages of research from R and D to DS-DP

Why Aurigene Pharmaceutical Services?

Multiple design or route options and complete design to delivery support

Capability across wide chemistry platforms

Library synthesis across various platforms

Lab facilities operating from two locations: Hyderabad and Bangalore

Service in all areas of drug discovery and development

Virtual Tour

Role of Peptide Synthesis Based Drugs

Role of Peptide Synthesis Based Drugs

Amino acids, peptides and proteins play multiple roles in the normal functioning of the body.Group of amino acids between 2 to 50 are called peptides. They often act as hormones and play diverse roles in the normal biological processes in the human body such as metabolism, intercellular signaling and neurotransmission.Peptide synthesis based drug have a high pote...

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Technology meets sustainability - How a complex API development process goes green

We are always looking for ways to enhance the sustainability of our products and services. Our team successfully developed a scalable manufacturing process for the API product of one of our Biotech clients using eco-friendly manufacturing technologies. Read the case study to learn more....

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Construction of a quinoline ring via a 3-component reaction in water: crystal structure analysis and H-bonding patterns of a 2-aryl quinoline


Montmorillonite K-10 mediated green and one-pot synthesis of 2-substituted quinolines has been accomplished via a 3-component reaction of aniline, aldehydes and ethyl 3,3- diethoxypropionate in the presence of air oxygen in water. The crystal structure analysis and H-bonding patterns of one compound prepared are presented. ...

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