Aurigene is a leading Contract Research, Development, and Manufacturing Organization (CRDMO) with over two decades of experience in drug discovery and development. Our mission is to accelerate the development and delivery of innovative medicines to patients by catalyzing the drug discovery process. In alignment with this mission, we are adding below set of tools to our service offerings.
Aurigene.AI: An AI-assisted drug discovery platform Aurimine: A virtual database comprising of 12+ billion compound.
These innovations reinforce our commitment to advancing drug discovery and bringing innovative medicines to realization.
Aurigene.AI
The drug discovery and development is a protracted, resource-intensive process involving substantial investments, often reaching millions of dollars. Unfortunately, nearly 90% of drug discovery programs face failure at various stages, primarily due to the lack of platforms capable of predicting success or failure in initial phases.
Recognizing this formidable challenge and aligning with Aurigene’s mission, our experts have developed an AI-assisted drug discovery platform Aurigene.AI. This is a one-of-a-kind platform created through the integration of advanced AI algorithms and computational/CADD approaches. This unique amalgamation expedites candidate nomination, supporting the entirety of drug discovery projects from hit identification to the selection of preclinical candidates.
The digital platform features a meticulously curated compound database which is validated with structure normalization rules and is ever-expanding using both in-house and public domain information. The robust database, which stands today at 180 million compounds, and 1.6 million validated bioassay data points, serves as a robust search engine and provides training data for the AI algorithms. The database is searchable through structure & property / semantic queries for getting relevant information required for a specific purpose.
Platform also offers significant amount of scope for customization by bringing several AI models onto one screen. This platform is a one stop shop for a wide variety of top-tier predictive and generative AI models, as well as computational/ CADD models. To date this platform consists of 11 generative AI, 4 predictive AI and 8 CADD/computational models. This modular and embedded design enables our scientific experts to cherry-pick the right set of models to be deployed for a specific application.
Being an end-to-end service provider, Aurigene is well equipped to quickly synthesize and run a variety of experimental assessments in both in-vitro and in-vivo . The results from the wet lab testing can be fed into our platform in real-time for training the AI models, enabling it to improve further. Creating this iterative-cycle, makes our platform unique and ensures that each new chemical design prediction made by the platform is increasingly accurate and reliable, and has the desired properties.
In conjunction with our synthetic chemistry and discovery biology services, this platform offers a comprehensive solution to clients eager to unveil and introduce their ground-breaking molecules to the market. It facilitates early detection of potential failures, paving the way for prompt reinitiation of candidate selection cycle. This approach significantly enhances the likelihood of successful drug discovery within a condensed timeframe and minimized costs.
Why Aurigene Pharmaceutical Services?
A robust platform that combines physics-based simulations and advanced AI algorithms
A customizable platform, that leverages best in class AI algorithms, CADD models and a meticulously curated and ever-expanding data-base
Learning system that enables “fail fast & iterate faster”
An end-to-end solution combining AI with Aurigene’s core expertise in synthesizing and experimentally testing the molecules
20+ years of experience in medicinal chemistry and discovery biology
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Hyderabad R and D Center
Bangalore R and D Center
Resources
JULY 05, 2023
How AI can accelerate drug discovery
Artificial Intelligence (AI) is a hot topic and a technology that will revolutionize and transform industries. In pharma, AI has the potential to advance clinical research and holds great promise for transforming the process involved in drug discovery, development, manufacturing, and distribution.Indicators are the rapidly growing number of AI-enabled biologics d...
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HPAPI Development at a Glance
The pharmaceutical industry's journey to improve patients' health has enhanced the number of more effective HPAPIs (High Potent Active Pharmaceutical Ingredient) in development pipelines. Traditionally, HPAPIs were exclusively concomitant with oncology therapeutics. ...
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Discovery, Development and Manufacturing Services
Aurigene Pharmaceutical Services is a leading contract research, development and manufacturing organization which provides range of services to enable your IND/NDA filing ...
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Technology meets sustainability - How a complex API development process goes green
We are always looking for ways to enhance the sustainability of our products and services. Our team successfully developed a scalable manufacturing process for the API product of one of our Biotech clients using eco-friendly manufacturing technologies. Read the case study to learn more....
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Formal synthesis of Cladospolide C & epi-Cladospolide C using R- (þ)-g-valerolactone as a chiral synthon
2019
The formal synthesis of Cladospolide-C and its analog is achieved by using enantiopure (R)-g evalerolactone 10. The significant points of this synthesis are the stereoselective dihydroxylation of a, bunsaturated ester 16 using Sharpless protocol, Wittig olefination of g evalerolactol 6 with triphenylphosphonium iodide salt 7, one pot selective oxidation ...
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A simple RP-HPLC method development and verification of the Dissolution of Bromelain-A Complex mixture of proteolytic enzymes, in delayed release tablets
2005
Bromelain is a complex natural mixture of proteolytic enzymes derived from pineapple (Ananas cosmosus), which has good therapeutic properties. Bromelain can be found in all tissues of pineapple plants, including the stem, fruit, and leaves. Bromelain plays an important role in the treatment of many diseases such as soft tissue inflammation and edema, deep derma, ...
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A sensitive and a simple RP-HPLC method development and verification for the quantitative estimation of Cholecalciferol in tablets
2005
Cholecalciferol, also known as Vitamin D3, is widely prescribed for the treatment osteomalacia and osteoporosis [1]. It also plays a key role in calcium and phosphorus homeostasis and skeletal mineralization [2]. IUPAC name of Cholecalciferol is (3β, 5Z, 7E) 9,10-secocholesta-5,7,10(19)-trien-3-ol, whose molecular weight is 384.64 g/mol and its molecular formula...
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A simple RP-HPLC method development and verification for the quantitative estimation of Sodium Butyrate in tablets
2005
Sodium butyrate is the sodium salt of butyric acid (Fig. 1), which exhibits various properties such as immune system modulator, antioxidant, and anti-inflammatory properties [1]. Furthermore, sodium butyrate is used as a promoter of growth in milk replacer formula for young calves [2]....
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