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Biotherapeutics Discovery Infrastructure Biotherapeutics Discovery Infrastructure

Biotherapeutics Discovery Infrastructure

High-quality large molecule discovery services supported by cutting-edge facilities with a focus on scientific innovation.

Aurigene Pharmaceutical services is rapidly positioning itself to provide high-quality and high-value large molecule discovery services in traditional and advanced drug modalities. We have capabilities for ‘Target to Preclinical Proof-of-Concept’. We provide wide range of large molecule discovery services from our R and D center in Hyderabad. Our R and D site is US FDA inspected. Our infrastructure is well-equipped with :

BSLII compliant labs Spectrophotometer Flow cytometer Mass Spectrometer (Agilent 6545 Q-TOF))
Analytical HPLC FPLCs (AKTA) SPR-BIAcore T200 Automated western (Simple JESS)
Automated liquid handler (Bravo) Lab scale LNP formulation set-up for mRNA Real-Time PCR (96 and 384 well plate) Gel documentation systems
Benchtop fermenter for yeast and E. coli Static incubators and shakers Multimode plate readers (Victor & Envision) Tape station
Preparatory ultracentrifuge Cell disruptor/French press Independent cell culture suites with microscope, liquid nitrogen storage, biosafety cabinets, static and shaker CO 2 incubators, Centrifuges. 

We adhere to strong data integrity and traceability framework which is embedded in our SOPs and IT systems. We have daily automatic backups for all generated data.

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Why meet us at CPHI Barcelona?

SEPTEMBER 04, 2023

Why meet us at CPHI Barcelona?

Discover the Opportunities: Visit Aurigene Pharmaceutical Services at CPHI BarcelonaThe Contract Research, Development and Manufacturing Organization (CRDMO) industry is a dynamic and rapidly evolving sector emerging as it plays a vital role in providing a wide range of services enabling drug companies to bring their products to market efficiently and effectively...

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Advancement in personalized medicine and how the CRDMO industry is part of the solution

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Personalized medicine is transforming the healthcare landscape by customizing treatment plans to individual patients’ unique genetic, clinical and environmental characteristics. These are effective and less invasive treatments for a wide range of conditions. Contract Research, Development and Manufacturing Organizations (CRDMOs) play an important role in enabli...

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Anti-Infective Drug Discovery

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Objective & Challenges: Objective was to identify an optimized anti-bacterial lead molecule with in vivo efficacy in relevant infection models an acceptable safety profile, and a patentable series.      Challenge was to develop a more efficacious compound than the reference standard.Study design: Compounds were designed and synth...

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Alternate end-game strategies towards Nirmatrelvir synthesis: Defining a continuous flow process for the preparation of an anti-COVID drug

2023

Scalable alternate end-game strategies for the synthesis of the anti-COVID drug molecule Nirmatrelvir (1,PF-07321332) have been described. The first involves a direct synthesis of 1 via amidation of the carboxylic acid 7 (suitably activated as a mixed anhydride with either pivaloyl chloride or T3P) with the ...

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