Project Requirement:
Cyclic peptides were to be analyzed for Kinetic solubility, Chrom Log D, MDCK, PAMPA, & Caco2 experiments, while overcoming the challenges associated with the impact of cyclization of peptides on in vitro experiments and bioanalysis
What were the challenges!
1. Nonspecific Binding (NSB)
2. Precipitation of peptides while spiking DMSO stock to buffer
3. Impact of pH on the compounds
4. Low recovery of peptides
5. Proteolysis in buffer and cellular enzymes
6. Inconsistent data
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