Enabling pre-clinical program of NEW Chemical Entities (NCEs) and providing one stop solution to customize the product in rapid phase. The activities recorded in the electronic lab notebook enforces online documentation in accordance to principles of ALCOA+. Our value proposition: Discovery Research Quick access to the building blocks and key intermediates Time is essence of synthesis Enable the supply for discovery research 100g to few kilos
Early phase development Quick access to Drug substance for toxicology studies Phase appropriate PRD to enable the scale up Non GMP facility: Flexible operation and accelerated delivery
Infrastructure
- 300+ fume hoods
- Kilo lab with cylindrical reactor varying 5L to 50L capacity
- Reactors from 500 L to 5000 L in Hyderabad & Bangalore
- 50L autoclave a with 20kg/Cm2 design pressure
- Pressure Nutsche filter, vaccum tray dryer and 20L rotavapor for downstream process
- Huber unit to operate the process -20 to 150 degree Celsius
- Internal network of strategic business partners
- We also have a potent kilo lab
Scientific Expertise
- Qualified PhDs and Postdocs in organic chemistry
- 150+ scientists in chemistry and analytical services
- 10+ process engineers and process safety engineers
Chemistry Capabilities
Expertise in
- Metal promoted cross coupling reaction
- Halogenation reactions
- High pressure hydrogenation
- Metal hydrate reactions
- Carbohydrates
- Lipids
- Peptides
- PEGylation
- Asymmetric synthesis
- Deuterated compound
- Heterocyclic chemistry
- Asymmetric hydrogenation
- Chiral synthesis
Analytical Capability
- High-performance liquid chromatography with varying detectors
- Gas chromatography
- Mass triple quad, 1H NMR Bruker
- Differential scanning calorimeter
- Micro calorimeter
- Reaction calorimetry
Why Aurigene Non-GMP Pilot Development Facility?
Quick turnaround of sample delivery
A strong scientific and analytical team
Infrastructure for mg to kg synthesis
Large network of qualified strategic business partners
Virtual Tour
Hyderabad R and D Center
Bangalore R and D Center
Development and Kilo Lab
Connect with our scientific experts for your drug discovery, development, and manufacturing needs
We understand that clear communication is essential to successful collaborations, and that's why we have a dedicated team that is always ready to help you. Whether you have questions about our services, want to discuss a potential partnership, or simply want to learn more about our company, we're here to help.
Our team of experts is dedicated to providing personalised solutions tailored to your unique needs. So, please don't hesitate to reach out to us. We look forward to hearing from you and helping you achieve your business goals.
Learning Resources
Neoantigen Specific T cells For Cancer Immunotherapy
An effective anti-tumor immune response in human is marked by presence of T cells reactive against neoantigens. Neoantigens are HLA-bound unique peptides arise from tumor-specific somatic mutations. Neoantigens are highly immunogenic because they are not present in normal tissues and hence bypass central thymic tolerance. The success of immune checkpoint blockade...
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Peptide Development and Manufacturing
Peptides are short chains of amino acids that are linked by peptide bonds. Several peptides linked together are called polypeptides. A protein contains one or more polypeptides. Therefore, proteins are long chains of amino acids held together by peptide bonds....
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Biologics Process Scale-up Services
Built on a solid platform of development and manufacturing scientist, we enable scale up doe both upstream and downstream processes. ...
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Expediting early development through innovative precision capsule filling technology
Introduction: Any new chemical entity (NCE) needs to undergo various stages of development such as preclinical and clinical trials before drug product is approved by regulatory agencies and available for patient. Formulations developed during early phases are simple formulations to enable phase appropriate studies like screening, dose ranging, toxicological and d...
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Revisiting the reaction of b-chloroacroleins with 2-aminophenol: a new observation
2008
The reaction of b-chloroacrolein with 1 equiv of 2-aminophenol in DMF proceeds smoothly to afford 11-hydroxy derivative of chromenoquinoline in good yield. This single pot method allows for a rapid access to a variety of chromenoquinolines or oxepinoquinolines depending on the nature of b-chloroacrolein used. The structures were established by spectroscopic data ...
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A simple RP-HPLC method development and verification of the Dissolution of Bromelain-A Complex mixture of proteolytic enzymes, in delayed release tablets
2005
Bromelain is a complex natural mixture of proteolytic enzymes derived from pineapple (Ananas cosmosus), which has good therapeutic properties. Bromelain can be found in all tissues of pineapple plants, including the stem, fruit, and leaves. Bromelain plays an important role in the treatment of many diseases such as soft tissue inflammation and edema, deep derma, ...
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A sensitive and a simple RP-HPLC method development and verification for the quantitative estimation of Cholecalciferol in tablets
2005
Cholecalciferol, also known as Vitamin D3, is widely prescribed for the treatment osteomalacia and osteoporosis [1]. It also plays a key role in calcium and phosphorus homeostasis and skeletal mineralization [2]. IUPAC name of Cholecalciferol is (3β, 5Z, 7E) 9,10-secocholesta-5,7,10(19)-trien-3-ol, whose molecular weight is 384.64 g/mol and its molecular formula...
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A simple RP-HPLC method development and verification for the quantitative estimation of Sodium Butyrate in tablets
2005
Sodium butyrate is the sodium salt of butyric acid (Fig. 1), which exhibits various properties such as immune system modulator, antioxidant, and anti-inflammatory properties [1]. Furthermore, sodium butyrate is used as a promoter of growth in milk replacer formula for young calves [2]....
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