A successful IDD program at Aurigene involves the participation of different domains like Medicinal Chemistry, Biochemistry, Cell & Molecular Biology, CADD, Analytical Chemistry, DMPK, Pharmacology, Safety and Toxicology, Scale-up & Process Development, Intellectual Property Management and Project Management. Amalgamation of 600+ highly skilled scientists in discovery team and state-of-the-art infrastructure at our Hyderabad and Bangalore sites, has resulted in successful delivery of many IND candidates. Our service is not limited to pharma and biotech companies, but also extend to animal health and crop science sectors.
We are flexible in our approach and offer a variety of business models including FTE & FFS mode of collaboration. In addition to the end-to-end IDD programs, we also offer a variety of “combination” packages to choose from, where our collaborators could select based on their unique requirements. Aurigene provides conducive environment for scientific innovation, which has resulted in several IND filings and a plethora of peer reviewed literature published in journals of international repute. We also bring with us a track record of solving complex challenges, using newer chemical modalities like peptides, PROTACs, lipids and Oligonucleotides.
Our Range of Services
- Synthetic Chemistry Services: With the advanced synthetic chemistry methodologies and innovative route designing, we provide milli-gram to multi-gram quantity of high purity compounds to support your research needs across the discovery cycle.
- Peptide Services: Our dedicated team of experts has a track record of handling peptides ranging from simple linear peptides to complex polypeptide analogues, from milli-gram to multi-gram quantities, for advancing your discovery and developmental research needs.
- Focused Library Synthesis: We have two decades of vast experience in working with global clients in custom synthesis of scaffolds and their usage in generating small to medium-sized custom libraries of target compounds.
- PROTACs: Expertise in the synthesis of PROTACs and Molecular Glues for targeted protein degradation, including the development and functionalization of various E3-ligase ligands such as CRBN, VHL, MDM2, and cIAP1.
- Oligonucleotides: We can synthesize 10-60-mer oligonucleotides up to 1 gram scale. We can perform all standard modifications, with or without backbone modification. We provide in-house capabilities for making any customized phosphoramidites.
- Computational Chemistry Services: The CADD & Informatics team at Aurigene work in tandem with chemistry and biology teams at every stage of the program. The CADD services facilitate the ideation and design of molecules to support hit identification to IND filing. Our team use various modelling applications and advance methods like de-novo design, ADMET prediction using AI/ML to fasten compound progress.
Mix and Match Programs
- Chemistry + In vitro Biology Programs
- Chemistry + CADD Programs
- Chemistry + DMPK Programs
- Chemistry + CADD + In vitro Biology programs etc.
IDD Offerings
Why Aurigene Pharmaceutical Services?
18 years’ experience in drug discovery
Various customer models
65+ Integrated Drug Discovery projects delivered
Speed: Our average candidate nomination time is 24-28 months
Capabilities to apply multiple modalities
Seamless integration into development stages
Integrated project management
Virtual Tour
Hyderabad R and D Center
Bangalore R and D Center
Pharmaceutical Analytical Services
Polymorph Screening
ADME/DMPK Services
Drug Formulation Services
In vivo Pharmacology
Medicinal Chemistry
Microbiology Testing
Peptide Synthesis
Development and Kilo Lab
Toxicology Studies
Contact Us
Resources
JUNE 28, 2022
Neoantigen Specific T cells For Cancer Immunotherapy
Neoantigen specific T cells for cellular cancer immunotherapy An effective anti-tumor immune response in human is marked by presence of T cells reactive against neoantigens. Neoantigens are HLA-bound unique peptides arise from tumor-specific somatic mutations. Neoantigens are highly immunogenic because they are not present in normal tissues and hence...
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Building successful long-term partnerships with CDMOs from early drug discovery through commercialization
Building successful long-term partnerships with CDMOs from early drug discovery through commercialization Maximizing efficiency in drug research, development, and manufacturing is crucial for turning new innovations into therapeutic and financial benefits. Over the past couple of decades, pharmaceutical companies have increasingly turned to contr...
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Technology meets sustainability - How a complex API development process goes green
We are always looking for ways to enhance the sustainability of our products and services. Our team successfully developed a scalable manufacturing process for the API product of one of our Biotech clients using eco-friendly manufacturing technologies. Read the case study to learn more. ...
Read MoreAlternate end-game strategies towards Nirmatrelvir synthesis: Defining a continuous flow process for the preparation of an anti-COVID drug
2023
Scalable alternate end-game strategies for the synthesis of the anti-COVID drug molecule Nirmatrelvir (1,PF-07321332) have been described. The first involves a direct synthesis of 1 via amidation of the carboxylic acid 7 (suitably activated as a mixed anhydride with either pivaloyl chloride or T3P) with the ...
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Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action.
2021
Mutations in MEK1/2 have been described as a resistance mechanism to BRAF/MEK inhibitor treatment. We report the discovery of a novel ATP-competitive MEK1/2 inhibitor with efficacy in wildtype (WT) and mutant MEK12 models. Starting from a HTS hit, we obtained selective, cellularly active ...
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Synthesis of Anti-covid Drug Nirmatrelvir Using Flow Chemistry
2021
Synthesis of the anti-covid therapeutic Nirmatrelvir by using flow chemistry to enhance efficiency of amide to nitrile conversion in a functionally and Stereochemically Embellished environment. ...
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Simple and efficient synthesis of imidazoquinoxalines and spiroquinoxalinones via pictect-spengler reaction using Wang resin, Synthetic Communications
2021
An efficient approach for the synthesis of various imidazoquinoxalines and spiroquinoxalinones has been reported from 2-(1H-imidazol-1-yl) aniline and .. ...
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