Our DMPK team is having expertise in both integrated drug discovery and standalone DMPK services with experience over 16 years. Our capabilities helped us to deliver more than 65 IDD projects. We design customized protocols and perform assays based on client or project requirements. The DMPK facility spanning an area of 10,000 sq.ft. in Bangalore and Hyderabad locations consists of state-of-the-art in vitro ADME and tissue culture labs, AAALAC accredited animal facility for in vivo PK studies in rats, mice & dogs and GLP & Non-GLP bioanalytical labs with high-end LC-MS/MS instruments.
In vitro ADME capable of high-throughput screening with best in industry turnaround times.
In vivo PK studies with various established surgical models.
Experience in DMPK studies and bioanalysis of small molecules, PROTACs, therapeutic peptides and biomarkers.
Automated compound management and data handling systems.
Turnaround time: In vitro Assays: 5 working days. In vivo PK Studies: 7 working days
Quality & accuracy
Compound management and data automation
Broad panel of in vitro ADME & in vivo PK study designs
Bioanalysis of small molecules, therapeutic peptides, biomarkers and complex molecules. Delivered 200+ GLP studies
JANUARY 04, 2021
DMPK studies play a crucial role in drug discovery for optimizing the drug-like properties of compounds or drug molecules. They enable researchers to rank compounds based on favorable pharmacokinetic properties associated with absorption, distribution, clearance, elimination (ADME) and DDI potential. The in-vitro assays and in-vivo animal studies provide informat...Read More
APRIL 24, 2023
JUNE 30, 2022
Maximizing efficiency in drug research, development, and manufacturing is crucial for turning new innovations into therapeutic and financial benefits. Over the past couple of decades, pharmaceutical companies have increasingly turned to contract development and manufacturing organizations (CDMOs) for collaborations as they seek more adaptable capacity and c...Read More
Project challenge: Complex carbohydrate chemistry involving a linear sequence of 10 chemical transformations, unstable intermediates and column chromatographic purications. Solution design: Process research and optimization was performed to develop a robust and scalable process which was implemented on commercial scale. Telescoping of reactions reduced the number...Read More
Scalable alternate end-game strategies for the synthesis of the anti-COVID drug molecule Nirmatrelvir (1,PF-07321332) have been described. The first involves a direct synthesis of 1 via amidation of the carboxylic acid 7 (suitably activated as a mixed anhydride with either pivaloyl chloride or T3P) with the ...Read More
Mutations in MEK1/2 have been described as a resistance mechanism to BRAF/MEK inhibitor treatment. We report the discovery of a novel ATP-competitive MEK1/2 inhibitor with efficacy in wildtype (WT) and mutant MEK12 models. Starting from a HTS hit, we obtained selective, cellularly active ...Read More
Synthesis of the anti-covid therapeutic Nirmatrelvir by using flow chemistry to enhance efficiency of amide to nitrile conversion in a functionally and Stereochemically Embellished environment. ...Read More
An efficient approach for the synthesis of various imidazoquinoxalines and spiroquinoxalinones has been reported from 2-(1H-imidazol-1-yl) aniline and .. ...Read More
ADME data helps scientists assess and optimize the absorption, distribution, metabolism, and excretion of the drug/NCE early in the drug discovery process. This helps to minimize late-stage failures in in-vivo safety and efficacy studies and clinical trials.
ADME testing involves various in-vitro and in-vivo assays used to assess the properties that determine the Absorption, Distribution, Metabolism, and Excretion (ADME) of NCEs/ drug molecules.
The ADME process involves the characterization of a drug by using different assays to determine its absorption, distribution, metabolism, and excretion properties. This data is critical to prioritize and advance drug/ NCEs for future development.
DMPK is the study of the drug-like properties of new chemical entities(NCE)/drugs to understand its metabolism and pharmacokinetic profile.
PK studies are an integral part of drug development. It helps to understand a new chemical entity (NCEs)/drug's pharmacokinetic behaviour in the body and involves the study of distribution, metabolism, clearance and bioavailability.
Pharmacokinetics (PK) is the response of the body to the drug. Whereas Pharmacodynamics (PD) is the action of the drug on our body.
For a period of 6 weeks, Oligos can be stored in T10E1 buffer at 37°C and for the long term, Oligonucleotides can be dried down and stored with or without TE buffer at -20°C.
Pharmacodynamics (PD) of a drug refers to the biochemical and physiological effects caused by the drug/NCE in the body.
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