At Aurigene Pharmaceutical Services, we offer solutions for all kinds of synthetic chemistry challenges, leveraging our expertise in synthetic chemistry as well as our thorough understanding of various aspects of drug discovery research. With a combination of 600+ highly skilled scientists and a state-of-the-art infrastructure spanned over two sites at Bangalore and Hyderabad, we can support all your synthetic chemistry needs. The team is well-versed in the synthesis of NCEs at all scales, from milligram quantity for a simple primary in vitro Biology and ADME screening needs, to gram scale synthesis for advanced profiling leading to IND filings.
Our discovery chemistry services encompasses heterocyclic chemistry, focused- libraries, peptides, PROTACs, lipids and oligonucleotides. With 40 modular labs equipped with synthesizers and advanced purification instruments, together with a well-equipped analytical infrastructure, we provide the best-in-class medicinal chemistry services to various biotech, pharmaceutical, agrochemical and specialty chemical companies. We are uniquely poised to be a perfect research partner for all your Drug Discovery needs, with a completely digitalized documentation process and compound management facility, an in-house stock of >50000 chemicals and our expertise in providing secure intellectual property.
90% of talent is PG or above
Integration of chemistry to biology and CDMO
State-of-the art facilities and modern infrastructure
Data driven decision making- CADD, informatics, advanced software platforms
50K+ compound inventory management system
20+ Years of legacy
Target identification to commercial manufacturing
JANUARY 04, 2021
Amino acids, peptides and proteins play multiple roles in the normal functioning of the body.Group of amino acids between 2 to 50 are called peptides. They often act as hormones and play diverse roles in the normal biological processes in the human body such as metabolism, intercellular signaling and neurotransmission.Peptide synthesis based drug have a high pote...Read More
The pharmaceutical industry's journey to improve patients' health has enhanced the number of more effective HPAPIs (High Potent Active Pharmaceutical Ingredient) in development pipelines. Traditionally, HPAPIs were exclusively concomitant with oncology therapeutics. ...Read More
Aurigene Pharmaceutical Services is a leading contract research, development and manufacturing organization which provides range of services to enable your IND/NDA filing ...Read More
We are always looking for ways to enhance the sustainability of our products and services. Our team successfully developed a scalable manufacturing process for the API product of one of our Biotech clients using eco-friendly manufacturing technologies. Read the case study to learn more....Read More
The formal synthesis of Cladospolide-C and its analog is achieved by using enantiopure (R)-g evalerolactone 10. The significant points of this synthesis are the stereoselective dihydroxylation of a, bunsaturated ester 16 using Sharpless protocol, Wittig olefination of g evalerolactol 6 with triphenylphosphonium iodide salt 7, one pot selective oxidation ...Read More
Scalable alternate end-game strategies for the synthesis of the anti-COVID drug molecule Nirmatrelvir (1,PF-07321332) have been described. The first involves a direct synthesis of 1 via amidation of the carboxylic acid 7 (suitably activated as a mixed anhydride with either pivaloyl chloride or T3P) with the ...Read More
Cholecalciferol, also known as Vitamin D3, is widely prescribed for the treatment osteomalacia and osteoporosis . It also plays a key role in calcium and phosphorus homeostasis and skeletal mineralization . IUPAC name of Cholecalciferol is (3β, 5Z, 7E)- 9,10-secocholesta-5,7,10(19)-trien-3-ol, whose molecular weight is 384.64 g/mol and its molecular formul...Read More
Mutations in MEK1/2 have been described as a resistance mechanism to BRAF/MEK inhibitor treatment. We report the discovery of a novel ATP-competitive MEK1/2 inhibitor with efficacy in wildtype (WT) and mutant MEK12 models. Starting from a HTS hit, we obtained selective, cellularly active ...Read More
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