At Aurigene Pharmaceutical Services, we offer solutions for all kinds of synthetic chemistry challenges, leveraging our expertise in synthetic chemistry as well as our thorough understanding of various aspects of drug discovery research. With a combination of 600+ highly skilled scientists and a state-of-the-art infrastructure spanned over two sites at Bangalore and Hyderabad, we can support all your synthetic chemistry needs. The team is well-versed in the synthesis of NCEs at all scales, from milligram quantity for a simple primary in vitro Biology and ADME screening needs, to gram scale synthesis for advanced profiling leading to IND filings.
Our discovery chemistry services encompasses heterocyclic chemistry, focused- libraries, peptides, PROTACs, lipids and oligonucleotides. With 40 modular labs equipped with synthesizers and advanced purification instruments, together with a well-equipped analytical infrastructure, we provide the best-in-class medicinal chemistry services to various biotech, pharmaceutical, agrochemical and specialty chemical companies. We are uniquely poised to be a perfect research partner for all your Drug Discovery needs, with a completely digitalized documentation process and compound management facility, an in-house stock of >50000 chemicals and our expertise in providing secure intellectual property.
Synthetic Chemistry Services
- Design-to-Delivery support across various chemistry platforms
- Milligram-scale to Gram-scale delivery of NCEs
- Expertise in solving complex chemistry challenges
- Experienced in parallel catalyst and ligand screening leading to quick resolution of synthetic bottlenecks
Peptide Services
- One stop solution for end to end (discovery-development-manufacturing) services in peptide space
- Proven track record of running integrated peptide drug discovery programs
- Close to two decades of experience in dealing with complex peptide modifications including peptide conjugation
- Long standing collaboration with leading peptide players
Focused Library Synthesis
- Experienced in generating small to medium-sized custom libraries
- In-house collection of building blocks to support custom libraries
- Parallel purification using Mass-Directed HPLC for high throughput
PROTACs
- A decade of experience working with PROTACs and molecular glues
- Analytical team well-versed in the purification of PRTOACs
- In-house library of Partial PROTACs for quick target engagement
Oligonucleotides
- Experience in synthesizing 10-60-mer oligonucleotides
- Synthesis of ASO, Aptamers and Si-RNAs
- Customized phosphoramidites and post-synthesis modifications
Niche Chemistry Areas
- Photo-redox and Organo-Electrochemistry
- C-H activation chemistry
- C-Si, C-P and C-Se bond-forming reactions
- Carbohydrates and nucleoside chemistries
- Steroids and Lipids
- Labelled compounds and Isotopes
Why Aurigene Pharmaceutical Services?
90% of talent is PG or above
Integration of chemistry to biology and CDMO
State-of-the art facilities and modern infrastructure
Data driven decision making- CADD, informatics, advanced software platforms
50K+ compound inventory management system
Integrated Services
Co-located Teams
20+ Years of legacy
Target identification to commercial manufacturing
Other Services
- Artificial intelligence (AI) Assisted Drug Discovery platform
- CADD and Informatics Services
- Custom Library Synthesis Services
- Custom Peptide Synthesis Services
- Discovery Biology Services
Artificial intelligence (AI) Assisted Drug Discovery platform
CADD and Informatics Services
Custom Library Synthesis Services
Custom Peptide Synthesis Services
Discovery Biology Services
Early Phase Development and Pilot Facility Services
Integrated Drug Discovery Services
Medicinal Chemistry Services
Oligonucleotide Synthesis Services
Pharmaceutical Analytical Chemistry Services
PROTAC Synthesis and Screening for Targeted Protein Degradation
Virtual Tour
Hyderabad R and D Center
Bangalore R and D Center
Medicinal Chemistry
Peptide Synthesis
Development and Kilo Lab
Resources
Role of Peptide Synthesis Based Drugs
Amino acids, peptides and proteins play multiple roles in the normal functioning of the body.Group of amino acids between 2 to 50 are called peptides. They often act as hormones and play diverse roles in the normal biological processes in the human body such as metabolism, intercellular signaling and neurotransmission.Peptide synthesis based drug have a high pote...
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HPAPI Development at a Glance
The pharmaceutical industry's journey to improve patients' health has enhanced the number of more effective HPAPIs (High Potent Active Pharmaceutical Ingredient) in development pipelines. Traditionally, HPAPIs were exclusively concomitant with oncology therapeutics. ...
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Discovery, Development and Manufacturing Services
Aurigene Pharmaceutical Services is a leading contract research, development and manufacturing organization which provides range of services to enable your IND/NDA filing ...
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Technology meets sustainability - How a complex API development process goes green
We are always looking for ways to enhance the sustainability of our products and services. Our team successfully developed a scalable manufacturing process for the API product of one of our Biotech clients using eco-friendly manufacturing technologies. Read the case study to learn more....
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Formal synthesis of Cladospolide C & epi-Cladospolide C using R- (þ)-g-valerolactone as a chiral synthon
2019
The formal synthesis of Cladospolide-C and its analog is achieved by using enantiopure (R)-g evalerolactone 10. The significant points of this synthesis are the stereoselective dihydroxylation of a, bunsaturated ester 16 using Sharpless protocol, Wittig olefination of g evalerolactol 6 with triphenylphosphonium iodide salt 7, one pot selective oxidation ...
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A simple RP-HPLC method development and verification of the Dissolution of Bromelain-A Complex mixture of proteolytic enzymes, in delayed release tablets
2005
Bromelain is a complex natural mixture of proteolytic enzymes derived from pineapple (Ananas cosmosus), which has good therapeutic properties. Bromelain can be found in all tissues of pineapple plants, including the stem, fruit, and leaves. Bromelain plays an important role in the treatment of many diseases such as soft tissue inflammation and edema, deep derma, ...
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A sensitive and a simple RP-HPLC method development and verification for the quantitative estimation of Cholecalciferol in tablets
2005
Cholecalciferol, also known as Vitamin D3, is widely prescribed for the treatment osteomalacia and osteoporosis [1]. It also plays a key role in calcium and phosphorus homeostasis and skeletal mineralization [2]. IUPAC name of Cholecalciferol is (3β, 5Z, 7E) 9,10-secocholesta-5,7,10(19)-trien-3-ol, whose molecular weight is 384.64 g/mol and its molecular formula...
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A simple RP-HPLC method development and verification for the quantitative estimation of Sodium Butyrate in tablets
2005
Sodium butyrate is the sodium salt of butyric acid (Fig. 1), which exhibits various properties such as immune system modulator, antioxidant, and anti-inflammatory properties [1]. Furthermore, sodium butyrate is used as a promoter of growth in milk replacer formula for young calves [2]....
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