Antibody, linker-payload, conjugation and analytics – we provide a one-stop solution for ADC discovery and development.
We understand the dynamic nature of the current ADC technology landscape and the complexities associated with it. Our team is well versed with a wide range of ADC technologies and is capable of adapting new technologies to support our client needs. We also provide expertise to develop novel liker technologies and cytotoxic payload optimization.
We offer a wide range of ADC services, and our team is competent at adapting new technologies to meet client requirements.
Linker Technologies
We offer services for designing and synthesizing ADC linkers and linker-drug conjugates. Based on the drug release mechanism, we design & synthesize different ADC linkers: Cleavable and non-cleavable linkers, self-immolation tracer-free linkers, and peptide linkers.
Conjugation Technologies
Our team carries out ADC conjugation services to accelerate the production of ADC constructs with quality attributes.
Amine (Lys) conjugation, thiol (Cys) conjugation, site-specific conjugation, enzymatic conjugation, glycoconjugation and click chemistry.
Payloads
According to clients’ requirements, we optimize payloads such as cytotoxic, non-cytotoxic, and biological payloads. Our team handles a wide range of cytotoxic payloads, including:
- Auristatins (MMAE and MMAF)
- Tubulysin
- PBD Dimer
- Maytansinoids (DM-1, DMO4)
- Duocarmycin
- Exatecans
ADC Discovery (Therapeutics and Tools or Reagents) and Development
Our ADC discovery programs are customized as per the target biology and desired mechanism of action. Specific screening strategies are designed and employed at a stage as early as antibody generation. Some of the early stage activities include screening and design of mAbs for internalization (or lack of it), effector function, off-site localization and half-life.
Rapid and comprehensive scouting of the linker-payload technology space can be plugged-in to identify the most desirable combinations of mAb, linker-payload and conjugation strategies. Stage appropriate in vitro screening and detailed evaluation of lead ADC molecules is carried out using customized assay platforms.
We also provide in vivo therapeutic evaluation, PK, and rodent toxicology assessment support for ADC candidates with appropriate bioanalytical methods customized for each program. Conjugation and purification process development takes into account each component of the ADC molecule. Quality, scalability, safety and cost-effectiveness concerns are addressed at each stage of process development.
ADC Analysis
A biomolecule is complex as an ADC and demands analytical assessment to ensure safety and quality. Routinely determined attributes during ADC analysis are
- DAR average
- Free-drug
- Conjugation site
- Aggregation
- Fragmentation
- Endotoxin
- Antigen binding affinity
- Plasma stability
- In vitro potency
Why Aurigene Pharmaceutical Services?
Site-specific conjugation technology
In-house linker library and Payload
Collaborative and solution driven
Analytical assessment to ensure safety and quality
Various commercial and customized linkers
Virtual Tour
Hyderabad R and D Center
Bangalore R and D Center
Contact Us
Resources
JUNE 28, 2022
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Building successful long-term partnerships with CDMOs from early drug discovery through commercialization
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Technology meets sustainability - How a complex API development process goes green
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2023
Scalable alternate end-game strategies for the synthesis of the anti-COVID drug molecule Nirmatrelvir (1,PF-07321332) have been described. The first involves a direct synthesis of 1 via amidation of the carboxylic acid 7 (suitably activated as a mixed anhydride with either pivaloyl chloride or T3P) with the ...
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Synthesis of Anti-covid Drug Nirmatrelvir Using Flow Chemistry
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2021
An efficient approach for the synthesis of various imidazoquinoxalines and spiroquinoxalinones has been reported from 2-(1H-imidazol-1-yl) aniline and .. ...
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