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Medical Chemistry

Navigating the Surge in Demand for Lipid Nano Carriers: Challenges and Future Perspectives

MAY 16, 2024

Analytical R&D

Challenges and winning strategies to develop an analytical method for Nitrosamines

MAY 15, 2024

CPHI Barcelona

Why meet us at CPHI Barcelona?

SEPTEMBER 04, 2023

Drug Development

A Brief Introduction to Click Chemistry and Bioorthogonal Chemistry

AUGUST 23, 2023

AI and Drug Discovery

How AI can accelerate drug discovery

JULY 05, 2023

Drug Development

“Bathtub Chemistry” - Necessity and Aspects of Process Research

MAY 19, 2023

Business Continuity

The importance of business continuity planning in CRDMO industry

NOVEMBER 16, 2023

Large Molecule Discovery Services

Neoantigen Specific T cells For Cancer Immunotherapy

JUNE 28, 2022

Pharmaceutical Services

Oligonucleotide as a novel class of therapeutic modality

JULY 02, 2021

Studies and Research

The influence of formulation development and its route of administration

JANUARY 04, 2021

Pharmaceutical Services

The Importance of Carbohydrate Synthesized Drugs

JANUARY 04, 2021

Development and Manufacturing

Application and Manufacturing of High Potent Active Pharmaceutical Ingredient (HPAPI)

JANUARY 04, 2021

Studies and Research

Role of Peptide Synthesis Based Drugs

JANUARY 04, 2021

Studies and Research

The Role of DMPK Studies in Drug Discovery

JANUARY 04, 2021

Development and Manufacturing

Application of mPEGs in Drug Discovery and Development

JANUARY 04, 2021

Drug Development

Importance of Route Scouting in Chemical Development

FEBRUARY 05, 2021

Development and Manufacturing

Introduction to PROTAC

FEBRUARY 08, 2021

Development and Manufacturing

Advantages of PROTACs over traditional drugs

JUNE 30, 2022

Development and Manufacturing

Emerging Trends in Solid State Phase Peptide Synthesis

FEBRUARY 23, 2021

CDMO Services

CDMO Brochure

AI-assisted Drug Discovery

AI-assisted Drug Discovery

Custom Peptide Synthesis cro

Custom Peptide Synthesis

Custom Peptide Synthesis cdmo

Peptide Synthesis

Cdmo Carbohydrates development

Carbohydrate

Anti-infective drug discovery

Anti-Infective Drug Discovery

Manufacturing an activated mPEG derivative

Manufacturing an activated mPEG derivative

Familiarization, process optimization and non- GMP manufacturing & supply of 3.0 kg of HPAPI product

Familiarization, process optimization and non- GMP manufacturing & supply of 3.0 kg of HPAPI product

Solid dispersion development to enhance solubility and oral bioavailability for rodent toxicology studies

Solid dispersion development to enhance solubility and oral bioavailability for rodent toxicology studies

Delivering 3 g dose of emetic and poorly bioavailable compound for 90 days repeated dose toxicity studies in dog

Delivering 3 g dose of emetic and poorly bioavailable compound for 90 days repeated dose toxicity studies in dog

Expediting early development through innovative precision capsule filling technology

Expediting early development through innovative precision capsule filling technology

Systematic formulation design - shorten development cost & time

Systematic formulation design - shorten development cost & time

Gastro Retentive Dosage Form

Gastro Retentive Dosage Form

Developing a methodology for In situ perfusion based combined tissue distribution and toxicity evaluation study

Developing a methodology for In situ perfusion based combined tissue distribution and toxicity evaluation study

Fixed Dose Combination Formulation

Fixed Dose Combination Formulation

Development of quick quantification method for muscle injury recovery evaluation in thermal injury mice model

Development of quick quantification method for muscle injury recovery evaluation in thermal injury mice model

Designing a novel methodology for the development of a macrocyclic peptide molecule for both formulation development and pre-clinical studies

Designing a novel methodology for the development of a macrocyclic peptide molecule for both formulation development and pre-clinical studies

Advancing a target molecule from in vitro studies to clinical supply: An innovative scientific solution

Advancing a target molecule from in vitro studies to clinical supply: An innovative scientific solution

Mitigating the manufacturing challenge of a New Chemical Entity comprising peptidomimetic molecule in order to achieve the desired scale-up

Mitigating the manufacturing challenge of a New Chemical Entity comprising peptidomimetic molecule in order to achieve the desired scale-up

How the re-designed synthesis of a complex carbohydrate can reduce cycle time

How the re-designed synthesis of a complex carbohydrate can reduce cycle time

Low yield challenges of a typical reaction

Low yield challenges of a typical reaction

Product development in a challenging IP landscape

Product development in a challenging IP landscape

Mitigating technical challenges and cost impacts by improved process design

Mitigating technical challenges and cost impacts by improved process design

Route scouting for an enantiomerically enriched Isoflavone

Route scouting for an enantiomerically enriched Isoflavone

Pharmacokinetic (PK) study of a compound following single dose intravenous and oral administration to female beagle dogs in a crossover design.

PK properties of a compound and study its effect on animal (dog) model

Technology meets sustainability - How a complex API development process goes green

Technology meets sustainability - How a complex API development process goes green

Immuno oncology cdmo

Immuno Oncology - Therapies and Challenges

long term partnership with cdmo

Building successful long-term partnerships with CDMOs from early drug discovery through commercialization

Accelerating Drug Discovery

Accelerating Drug Discovery Through Innovative Partnerships

CDMO white paper

Evolution in Pharma Industry and Demand for Integrated CDMO

Peptide Development and Manufacturing

Peptide Development and Manufacturing

A sensitive and a simple RP-HPLC method development and verification for the quantitative estimation of Cholecalciferol in tablets

A simple RP-HPLC method development and verification for the quantitative estimation of Sodium Butyrate in tablets

Formulation Development and Characterization of ION and PH Dual Activated Nasal IN-SITU Gel Containing Levodopa and Carbidopa for the treatment of Parkinson’s Disease

An efficient four-component protocol for synthesis of poly-substituted pyridines with SiO2 as a robust recyclable catalyst

Alternate end-game strategies towards Nirmatrelvir synthesis: Defining a continuous flow process for the preparation of an anti-COVID drug

A Sensitive and a Simple RP-HPLC Method Development and Verification for the Quantitative Estimation of Cholecalciferolin Tablets

Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action.

Synthesis of Anti-covid Drug Nirmatrelvir Using Flow Chemistry

Simple and efficient synthesis of imidazoquinoxalines and spiroquinoxalinones via pictect-spengler reaction using Wang resin, Synthetic Communications

Polycyclic Aromatic Compounds: A Simple and Efficient [(n-Bu3Sn)2MO4]n Catalyzed Synthesis of Quinazolinones and Dihydroquinazolinones

Wang-OSO 3 H catalyzed green synthesis of bioactive isoindolo[2,1- a ]quinazoline-5,11–dione derivatives: An unexpected observation

Urea as an Ammonia Surrogate in the Hantzsch’s Synthesis of Polyhydroquinolines / 1,4-dihydropyridines under Green Reaction Conditions

Ultrasound assisted rapid synthesis of mefenamic acid based indole derivatives under ligand free Cu-catalysis: Their pharmacological evaluation

Base mediated spirocyclization of quinazoline: one-step synthesis of spiro-isoindolinone dihydroquinazolinones

Dhananjaya, G., AV Dhanunjaya Rao, Kazi Amirul Hossain, Venkateswara Rao Anna, and Manojit Pal. "In silico studies and β-cyclodextrin mediated neutral synthesis of 4-oxo-4, 5, 6, 7-tetrahydroindoles of potential biological interest." Tetrahedron Letters 6

Formal synthesis of Cladospolide C & epi-Cladospolide C using R- (þ)-g-valerolactone as a chiral synthon

Lipoplex-based therapeutics for effective oligonucleotide delivery: a compendious review

Amberlite-15 promoted an unprecedented aza Michael rearrangement for one pot synthesis of dihydroquinazolinone compounds

A convergent approach towards the synthesis of the 2-alkylsubstituted tetrahydroquinoline alkaloid ()-cuspareine

A diastereoselective synthesis of boceprevir's gem-dimethyl bicyclic [3.1.0] proline intermediate from an insecticide ingredient ciscypermethric acid

Synthesis of (+)-Patulolide C Using R-(+)-g-Valerolactone as a Chiral Synthon.

Novel highly selective peroxisome proliferator-activated receptor d (PPARd) modulators with pharmacokinetic properties suitable for once-daily oral dosing

A cascade reaction for the new and direct synthesis of indolofuroquinoxalines

Synthesis of 2-hydroxy-3-alkyl-2-phenyl-2,3- dihydroquinazolin-4(1H)-one via molybdenum hexacarbonyl mediated CO gas- and ligand free carbonylative reactions

An efficient and convenient protocol for the synthesis of tetracyclic isoindolo[1,2-a]quinazoline derivatives

A concise stereoselective synthesis of (+)-1-deoxy-6-epicastanospermine

A Simple Approach for the Synthesis of Fused Quinazoline-Based Tetracyclic Compounds via a Multicomponent Reaction Strategy

Stereoselective synthesis of (R)-() and (S)-(+)-phoracantholide I from (R)-(+)-c-valerolactone

Concise and highly stereoselective syntheses of D-fagomine and 2-epi-fagomine

A new strategy for accessing (S)-1-(furan-2-yl)pent-4-en-1-ol: a key precursor of Ipomoeassin family of compounds and C1–C15 domain of halichondrins

FeF3-catalyzed MCR in PEG-400: ultrasound assisted synthesis of N-substituted 2- aminopyridines

Development of a Chemoenzymatic Process for Dehydroepiandrosterone Acetate Synthesis

Discovery of (R,E)‑N‑(7-Chloro-1-(1-[4-(dimethylamino)but-2- enoyl]azepan-3-yl)‑1H‑benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Muta...

A metal catalyst-free and one-pot synthesis of (3,4- dihydro-2H-benzo[b][1,4]oxazin-2-yl)methanol derivatives in water

An efficient one pot synthesis of 2-amino quinazolin-4(3H)-one derivative via MCR strategy

Sulfonic acid functionalized Wang resin (Wang-OSO3H) as polymeric acidic catalyst for the eco-friendly synthesis of 2,3-dihydroquinazolin-4(1H)-ones

A short diastereoselective synthesis of cis-(2S,4S) and cis-(2R,4R)-4- hydroxyprolines

A greener approach towards double heteroarylation of N, O and S nucleophiles: synthesis of bioactive polynuclear fused Nheteroarenes

Diastereoselective total synthesis of piperidine alkaloids: (2R,5R)- 5-hydroxyhomopipecolic acid and (2R,5R,8R)-5-hydroxysedamine

Diversity oriented concise asymmetric synthesis of azasugars: a facile access to L-2,3-trans-3,4-cis-dihydroxyproline and (3S,5S)-3,4,5-trihydroxypiperidine

Discovery of O-(3-carbamimidoylphenyl)-L-serine amides as matriptase inhibitors using a fragment-linking approach

Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs)

A simple access to N-(un)substituted isoquinolin1(2H)-ones: unusual formation of regioisomeric isoquinolin-1(4H)-ones

Reactions of salicylaldehydes with activated terminal alkynes in aqueous media: synthesis of 3- substituted 4-hydroxy chromenes as potential cytotoxic agents

An oxidative amidation and heterocyclization approach for the synthesis of β-carbolines and dihydroeudistomin Y

Synthesis of tetrahedral diarylheptanoid ent-diospongin A and epimer-diospongin B by employing Julia–Kocienski olefination

Synthesis of tetrahedral diarylheptanoid ent-diospongin A and epimer-diospongin B by employing Julia–Kocienski olefination

Applications of Gage Reproducibility & Repeatability (GRR): Understanding and Quantifying the Effect of Variations from Different Sources on a Robust Process Development

Effect of Aqueous Polyethylene Glycol on 1,3-Dipolar Cycloaddition of Benzoylnitromethane/Ethyl 2-Nitroacetate with Dipolarophiles: Green Synthesis of Isoxazoles and Isoxazolines

3‑Alkoxy-pyrrolo[1,2‑b]pyrazolines as Selective Androgen Receptor Modulators with Ideal Physicochemical Properties for Transdermal Administration

Optimization of Spray Drying Process using Central Composite Design (CCD)

Formulation and Evaluation of Controlled Porosity Osmotic Drug Delivery System of Metoprolol Succinate

Synthesis of enantiomerically pure N-(2,3-dihydroxypropyl)arylamides via oxidative esterification

Cu-catalyzed coupling-cyclization in PEG 400 under ultrasound: a highly selective and greener approach towards isocoumarins

Diastereoselective total synthesis of 3,6-disubstituted piperidine alkaloids, (3R,6S)-epi-pseudoconhydrine and (3R,6R)-pseudoconhydrine

Identification of a Novel Series of Orexin Receptor Antagonists with a Distinct Effect on Sleep Architecture for the Treatment of Insomnia

Construction of a six-membered fused N-heterocyclic ring via a new 3-component reaction: synthesis of (pyrazolo)pyrimidines/pyridinesw

Construction of a quinoline ring via a 3-component reaction in water: crystal structure analysis and H-bonding patterns of a 2-aryl quinoline

An Efficient and Practical Synthesis of Aryl and Hetaryl a-Keto Esters

Synthesis of Isoquinoline Alkaloids via Oxidative Amidation–Bischler– Napieralski Reaction

Iodine catalyzed four-component reaction: a straightforward one-pot synthesis of functionalized pyrroles under metal-free conditions

N-heterocyclic carbene-mediated hydroacylation–Sonogashira/Heck/Suzuki coupling in a single pot: A new cascade reaction

Synthesis of novel 5-alkyl/aryl/heteroaryl substituted diethyl 3,4-dihydro-2H-pyrrole-4,4-dicarboxylates by aziridine ring expansion of 2-[(aziridin-1-yl)-1-alkyl/ aryl/heteroaryl-methylene]malonic acid diethyl esters

Yb(OTf)3 catalyzed new cascade reaction: a facile assembly of fused quinazolinones

Transition metal mediated construction of pyrrole ring on 2,3-dihydroquinolin-4(1H)-one: synthesis and pharmacological evaluation of novel tricyclic heteroarenes

A Concise and Cascade Synthesis of Batracylin and Substituted Isoindolo- [1,2-b]quinazolin-12(10H)-ones

A Concise and Convergent Synthesis of Luotonin B and E

Design and Development of a Fixed Dose Combination (FDC) of Delayed-Extended Release Niacin and a Flushing Modulator For Sequential Release

Optimization of formulation and process variable of nanosuspension: An industrial perspective

A highly effective synthesis of 2-alkynyl-7-azaindoles: Pd/C-mediated alkynylation of heteroaryl halides in water

Revisiting the reaction of b-chloroacroleins with 2-aminophenol: a new observation

Tandem versus single C–C bond forming reaction under palladium–copper catalysis: regioselective synthesis of a-pyrones fused with thiophene

Palladium-mediated synthesis of 5-substituted 4-alkynylthieno[2,3-c]pyran-7-onesq

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