• search
In vitro Genotoxicity Testing Services In vitro Genotoxicity Testing Services

In vitro Genotoxicity Testing Services

Aurigene is committed to provide rapid and solution driven in vitro Genotoxicity testing services.

Genotoxicity is an adverse effect of a chemical on genetic material via variety of mechanisms, including mutation. In vitro Genotoxicity testing is very crucial to determine potential carcinogenic or mutagenic compounds that can cause genetic alterations in somatic or germ cells, and this information is used in regulatory decision-making. Mutagenicity (gene mutation and structural and numerical chromosomal alterations) is one of the six basic testing areas that have been adopted by the Organization for Economic Co-operation and Development (OECD, 2011) as the minimum requirement to screen high-production volume chemicals for toxicity.

Speak to our experts

Three Major Endpoints of Genetic Damage

  • Gene mutation (i.e. point mutations or deletions or insertions that affect single or blocks of genes)
  • Clastogenicity (i.e. structural chromosome changes)
  • Aneuploidy (i.e. the occurrence of one or more extra or missing chromosomes, leading to an unbalanced chromosome complement).

In vitro Genotoxicity Testing

  • Bacterial reverse mutation test (OECD 471)
  • In vitro chromosomal aberration test using human blood lymphocytes (OECD 473)
  • In vitro micronucleus test using human blood lymphocytes (OECD 487)
  • Mammalian cell gene mutation assay (OECD 490)

Why Aurigene Pharmaceutical Services?

Combination of tests to assess genetic damage

State-of-the-art facilities

Virtual Tour

Oligonucleotide as a novel class of therapeutic modality

Oligonucleotide as a novel class of therapeutic modality

Oligonucleotides as a therapeutic class is a revolutionary approach to discover new and important therapeutic agents for treating human diseases. RNA-based intervention at times works in cases where other modalities do not work. For example, it may help in treating inborn errors in metabolism, genetic disorders and rareOligonucleotide therapeutics is the use of c...

Read More

Gastro Retentive Dosage Form

Introduction: An orally-available anti-diabetic candidate that simultaneously targets all three key organs of diabetes: Pancreas, Liver and Muscles. This drug targets the two main defects seen in patients with type 2 diabetes: The pancreas by increasing insulin secretion, in a glucose-dependent manner; and the muscles and liver by decreasing the excess production...

Read More

A metal catalyst-free and one-pot synthesis of (3,4- dihydro-2H-benzo[b][1,4]oxazin-2-yl)methanol derivatives in water


A robust and metal catalyst-free method has been developed for the general and green synthesis of racemic (3,4-dihydro-2H-benzo[b][1,4] oxazin-2-yl)methanol derivatives. This simple, mild and practical method involves the reaction of 2-aminophenols with ()-epichlorohydrin in the presence of NaOH in water at room temperature. The reaction features high regioselec...

Read More
View All

You are about to leave Aurigene Pharmaceutical Services and affiliates website. Aurigene Pharmaceutical Services assumes no responsibility for the information presented on the external website or any further links from such sites. These links are presented to you only as a convenience, and the inclusion of any link does not imply endorsement by Aurigene Pharmaceutical Services.

If you wish to continue to this external website, click Proceed.