The pharmaceutical microbiology testing service at Aurigene is supported by BSL-2 compliant lab and a dedicated in vivo facility for bacterial and fungal infection murine disease models. Our team has collaborated on numerous anti-bacterial and anti-fungal agent discovery projects with innovator pharma companies. We have a dedicated team of scientists and allied staff with vast experience in anti-infective drug discovery projects. We have established in vitro assays and in vivo murine efficacy models.
We also support generic product filings through bioequivalance studies of in vitro time-kill kinetics against reference drug.
In vitro Pharmaceutical Microbiology Testing Services
- Pharmacodynamic studies: Drug-organism interaction
- MIC and MBC: Susceptibility indicators; major parameters used to quantify the activity of an antibacterial agent against the target pathogen
- Time kill kinetics: Information on the time course and rate of antimicrobial activity
- PAE and PA-SME: Information on persistent effects of antibacterial agents
- Others: Antimicrobial combination/effect of serum proteins on MIC/ biofilm studies
In vivo Pharmaceutical Microbiology Testing Services
- Systemic infection models: Acute lethal model to generate POC and determine ED50 - primary screening
- Respiratory tract infection models: Test efficacy of NCEs in highly vascularized tissue like lungs
- Thigh infection models: Test efficacy of NCEs in poorly vascularized tissues like thighs
- Urinary tract infection models: Testability of NCEs to clear UTIs
- Organ burden models: Testability of NCEs to clear the disseminated infection
Why Aurigene Pharmaceutical Services?
Submissions to the US FDA
Highly qualified & experienced scientists
Audited by the US FDA with Zero 483 in 2019
BSL-2 compliant microbiology lab
Wide range of infectious models & microbiology assay capabilities
Other Services
Virtual Tour
Hyderabad R and D Center
Bangalore R and D Center
Microbiology Testing
Resources
JUNE 28, 2022
Neoantigen Specific T cells For Cancer Immunotherapy
An effective anti-tumor immune response in human is marked by presence of T cells reactive against neoantigens. Neoantigens are HLA-bound unique peptides arise from tumor-specific somatic mutations. Neoantigens are highly immunogenic because they are not present in normal tissues and hence bypass central thymic tolerance. The success of immune checkpoint blockade...
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Evolution in Pharma Industry and Demand for Integrated CDMO
The pharma industry is evolving and a demand for integrated CDMOs, which can help accelerating innovations, is part of the evolution....
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Physiochemical Characterization Services
Backed by our strong chemistry, we enable “Finger-print” protein structure and functional characterization for proteins from naked proteins to hyperglycosylated or derivatized proteins. ...
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Fixed Dose Combination Formulation
Introduction: A fixed dose combination (FDC) includes two or more active pharmaceutical ingredients (APIs) combined in a single dosage form. Fixed dose combination (FDC) product is expected to provide below advantages: Improved medication compliance by reducing the pill burden of patients. To achieve synergistic activity If combinations include doses of each drug...
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Synthesis of 2-hydroxy-3-alkyl-2-phenyl-2,3- dihydroquinazolin-4(1H)-one via molybdenum hexacarbonyl mediated CO gas- and ligand free carbonylative reactions
2016
Carbon monoxide gas and ligand-free conditions were developed for the synthesis of 2-hydroxy-3-alkyl-2-phenyl-2,3-dihydroquinazolin4(1H)-one via catalytic carbonylation with molybdenum hexacarbonyl as an efficient carbonylating agent for the three-component reaction of isatoic anhydride, amine, iodobenzene. Mo(CO)6 is a solid carbon monoxide source. The quinazoli...
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Alternate end-game strategies towards Nirmatrelvir synthesis: Defining a continuous flow process for the preparation of an anti-COVID drug
2005
Scalable alternate end-game strategies for the synthesis of the anti-COVID drug molecule Nirmatrelvir (1,PF-07321332) have been described. The first involves a direct synthesis of 1 via amidation of the carboxylic acid 7 (suitably activated as a mixed anhydride with either pivaloyl chloride or T3P) with the ...
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Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action.
2005
Mutations in MEK1/2 have been described as a resistance mechanism to BRAF/MEK inhibitor treatment. We report the discovery of a novel ATP-competitive MEK1/2 inhibitor with efficacy in wildtype (WT) and mutant MEK12 models. Starting from a HTS hit, we obtained selective, cellularly active ...
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Synthesis of Anti-covid Drug Nirmatrelvir Using Flow Chemistry
2005
Synthesis of the anti-covid therapeutic Nirmatrelvir by using flow chemistry to enhance efficiency of amide to nitrile conversion in a functionally and Stereochemically Embellished environment. ...
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