Experience and expertise are key to successful new drug development. There are various stages to a drug development program that need alignment of objectives and optimization of resource utilization. While the clinical success or failure of a drug is majorly influenced by its therapeutic potential, how systematically it is developed has an equal contribution to its success.
By integrating the development and manufacturing of drug substance and formulations, we are uniquely positioned to offer a significant advantage to customers that leverage the technical integration of both teams. 
The End-to-end Integration Benefits
- Continuous feedback-loop for a better quality of development between API and formulation teams
- Co-located teams share & leverage knowledge at each stage of product development and manufacturing
- Cost of common procurement such as analytical columns as reagents, logistics, and repeat analysis are minimized
- Parallel activities are better aligned benefiting project timelines
- Benefits of uniform quality systems at R and D and manufacturing
Why Aurigene Pharmaceutical Services?
20+ years legacy of providing integrated API and formulation services
Fit-for-purpose development strategy
Co-located cross-functional teams
Services across the product lifecycle
US FDA-inspected GMP facilities
Other Services
Virtual Tour
Hyderabad R and D Center
Bangalore R and D Center
Drug Formulation Services
Resources
APRIL 24, 2023
The importance of business continuity planning in CRDMO industry
Both natural and unnatural catastrophic events inflict negative consequences due to the ever-increasing interconnectedness of the global economy. Those consequences are certain to last for longer duration. e.g.; The Covid-19 pandemic is still having a negative impact on the global economy. Maintaining continuity is critical for all businesses, but perhaps no othe...
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HPAPI Molecule from Development to Market
The global Highly Potent Active Pharmaceutical Ingredients (HPAPI) market is expected to reach USD 26.84 Billion by 2023 from USD 17.72 Billion in 2018, at a CAGR 8.7%....
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Physiochemical Characterization Services
Backed by our strong chemistry, we enable “Finger-print” protein structure and functional characterization for proteins from naked proteins to hyperglycosylated or derivatized proteins. ...
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Designing a novel methodology for the development of a macrocyclic peptide molecule for both formulation development and pre-clinical studies
Background: An innovator company based in UK contacted us to support for the development of macro cyclic peptide molecule for pre-clinical studies. This peptide compound has been identified as potential candidate for the “Vaccination booster for elderly” under the therapeutic category of immunology. The synthesis of this compound posed many challenges such as...
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Cu-catalyzed coupling-cyclization in PEG 400 under ultrasound: a highly selective and greener approach towards isocoumarins
2013
The combination of CuI–K2CO3-PEG 400 facilitated the couplingcyclization of o-iodobenzoic acid with terminal alkynes under ultrasound, affording a greener and practical approach towards 3-substituted isocoumarins with remarkable regioselectivity. This inexpensive and Pd and ligand free methodology gave rise to various isocoumarins of potential pharmacological i...
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Alternate end-game strategies towards Nirmatrelvir synthesis: Defining a continuous flow process for the preparation of an anti-COVID drug
2005
Scalable alternate end-game strategies for the synthesis of the anti-COVID drug molecule Nirmatrelvir (1,PF-07321332) have been described. The first involves a direct synthesis of 1 via amidation of the carboxylic acid 7 (suitably activated as a mixed anhydride with either pivaloyl chloride or T3P) with the ...
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Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action.
2005
Mutations in MEK1/2 have been described as a resistance mechanism to BRAF/MEK inhibitor treatment. We report the discovery of a novel ATP-competitive MEK1/2 inhibitor with efficacy in wildtype (WT) and mutant MEK12 models. Starting from a HTS hit, we obtained selective, cellularly active ...
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Synthesis of Anti-covid Drug Nirmatrelvir Using Flow Chemistry
2005
Synthesis of the anti-covid therapeutic Nirmatrelvir by using flow chemistry to enhance efficiency of amide to nitrile conversion in a functionally and Stereochemically Embellished environment. ...
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