Our pharmacokinetic (PK) studies in rats, mice and dogs help in understanding the characteristics of New Chemical entities (NCEs). Our PK studies are highly efficient in predicting the exposure while determining the dosage levels and frequencies for testing in preclinical in vivo animal disease efficacy models. We conduct PK studies for small and large molecules at our state-of-the-art laboratories and vivarium. Our DMPK scientists help understand the drug's AUC, clearance, half-life, the volume of distribution, Cmax, and Cmin in the body over time.
Industry’s leading CRO for Pharmacokinetic Studies A variety of surgical animal PK models Track record of delivering 200+ GLP studies GLP accredited bioanalysis labs for PK studiesNon-GLP bioanalysis facilities for PK studiesA wide range of administration routes
Why Aurigene Pharmaceutical Services?
Variety of surgical animal PK models
Track record of delivering 200+ GLP studies
GLP accredited bioanalysis labs for PK studies
Non-GLP bioanalysis facilities for PK studies
A wide range of administration routes
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Resources
JUNE 28, 2022
Neoantigen Specific T cells For Cancer Immunotherapy
Neoantigen specific T cells for cellular cancer immunotherapy An effective anti-tumor immune response in human is marked by presence of T cells reactive against neoantigens. Neoantigens are HLA-bound unique peptides arise from tumor-specific somatic mutations. Neoantigens are highly immunogenic because they are not present in normal tissues and hence...
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Building successful long-term partnerships with CDMOs from early drug discovery through commercialization
Building successful long-term partnerships with CDMOs from early drug discovery through commercialization Maximizing efficiency in drug research, development, and manufacturing is crucial for turning new innovations into therapeutic and financial benefits. Over the past couple of decades, pharmaceutical companies have increasingly turned to contr...
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Technology meets sustainability - How a complex API development process goes green
We are always looking for ways to enhance the sustainability of our products and services. Our team successfully developed a scalable manufacturing process for the API product of one of our Biotech clients using eco-friendly manufacturing technologies. Read the case study to learn more. ...
Read MoreAlternate end-game strategies towards Nirmatrelvir synthesis: Defining a continuous flow process for the preparation of an anti-COVID drug
2023
Scalable alternate end-game strategies for the synthesis of the anti-COVID drug molecule Nirmatrelvir (1,PF-07321332) have been described. The first involves a direct synthesis of 1 via amidation of the carboxylic acid 7 (suitably activated as a mixed anhydride with either pivaloyl chloride or T3P) with the ...
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Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action.
2021
Mutations in MEK1/2 have been described as a resistance mechanism to BRAF/MEK inhibitor treatment. We report the discovery of a novel ATP-competitive MEK1/2 inhibitor with efficacy in wildtype (WT) and mutant MEK12 models. Starting from a HTS hit, we obtained selective, cellularly active ...
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Synthesis of Anti-covid Drug Nirmatrelvir Using Flow Chemistry
2021
Synthesis of the anti-covid therapeutic Nirmatrelvir by using flow chemistry to enhance efficiency of amide to nitrile conversion in a functionally and Stereochemically Embellished environment. ...
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Simple and efficient synthesis of imidazoquinoxalines and spiroquinoxalinones via pictect-spengler reaction using Wang resin, Synthetic Communications
2021
An efficient approach for the synthesis of various imidazoquinoxalines and spiroquinoxalinones has been reported from 2-(1H-imidazol-1-yl) aniline and .. ...
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Frequently asked questions
Why is pharmacokinetics important in drug discovery?
The characteristic study of pharmacokinetics of drugs in drug development is crucial to ensure its safety and efficacy along with optimizing its ADME properties and other parameters to achieve the desired clinical efficacious candidate.
What is the purpose of pharmacokinetic studies in Aurigene?
Pharmacokinetic studies in Aurigene are carried out to assess the potency of the drug compound by examining the parameters on elimination, half-lives, and ADME properties and help scientists to design safer pre clinical and clinical trials.
What is the process followed during pharmacokinetic studies in Aurigene?
The standard pharmacokinetic process involves characterizing the potential drug by studying the ADME parameters. Depending upon the single or repeated dose the blood and urine samples are analyzed to determine exposure, dose levels, and preclinical testing.
What are the parameters considered during pharmacokinetic studies in Aurigene?
Pharmacokinetic studies in animals involve validating the necessary parameters on ADME along with clearance studies, half-life, bio availability, volume of distribution, and protein drug interactions.
What are the benefits of pharmacokinetic studies?
Pharmacokinetic study validates and ensures the safety and efficacy of drugs during pre-clinical and clinical trials by analyzing the ADME properties. It also provides data regarding drug-drug interactions and the disposition of a drug.
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