Our pharmacokinetic (PK) studies in rats, mice and dogs help in understanding the characteristics of New Chemical entities (NCEs). Our PK studies are highly efficient in predicting the exposure while determining the dosage levels and frequencies for testing in preclinical in vivo animal disease efficacy models. We conduct pharmacokinetic (PK) studies for small and large molecules at our state-of-the-art laboratories and vivarium. Our DMPK scientists help understand the drug's AUC, clearance, half-life, the volume of distribution, Cmax, and Cmin in the body over time.
Industry’s leading CRO for Pharmacokinetic Studies A variety of surgical animal PK models Track record of delivering 200+ GLP studies GLP accredited bioanalysis labs for PK studiesNon-GLP bioanalysis facilities for PK studiesA wide range of administration routes
Variety of surgical animal PK models
Track record of delivering 200+ GLP studies
GLP accredited bioanalysis labs for PK studies
Non-GLP bioanalysis facilities for PK studies
A wide range of administration routes
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Peptides are short chains of amino acids that are linked by peptide bonds. Peptides are highly specific and offer improved toxicological profiles. Peptides are produced using one of three synthesis methods: Solid phase peptide synthesis, liquid phase pepide synthesis or a hybrid approach.Solid-phase peptide synthesis(SPPS) is one of the most commonly used techniq...
Read MoreThe global Highly Potent Active Pharmaceutical Ingredients (HPAPI) market is expected to reach USD 26.84 Billion by 2023 from USD 17.72 Billion in 2018, at a CAGR 8.7%....
Read MoreBacked by our strong chemistry, we enable “Finger-print” protein structure and functional characterization for proteins from naked proteins to hyperglycosylated or derivatized proteins. ...
Read MoreIntroduction: A fixed dose combination (FDC) includes two or more active pharmaceutical ingredients (APIs) combined in a single dosage form. Fixed dose combination (FDC) product is expected to provide below advantages: Improved medication compliance by reducing the pill burden of patients. To achieve synergistic activity If combinations include doses of each drug...
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Synthesis of polyhydroquinolines via Hantzsch’s multicomponent reaction (MCR) involves the use of a hygroscopic and moderately toxic ammonium salt as one of the key reactants. In our effort,...
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Drug Delivery System (DDS) has been used successfully in the past few decades to cure illnesses and enhance health because of its improved systemic circulation and ability to regulate the drug's pharmacological action. As pharmacology and pharmacokinetics advanced, the idea of controlled release emerged, demonstrating the significance of drug release in assessing...
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Proteolysis-targeting chimera (PROTACs) represents a promising modality that has gained significant attention for cancer treatment. Using PROTAC technology, we synthesized novel structurally modified paullone-based PROTACs using Cereblon (CRBN) and Von Hippel–Lindau (VHL) E3 ligands....
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Bromelain is a complex natural mixture of proteolytic enzymes derived from pineapple (Ananas cosmosus), which has good therapeutic properties. Bromelain can be found in all tissues of pineapple plants, including the stem, fruit, and leaves. Bromelain plays an important role in the treatment of many diseases such as soft tissue inflammation and edema, deep derma, ...
Read MoreThe characteristic study of pharmacokinetics of drugs in drug development is crucial to ensure its safety and efficacy along with optimizing its ADME properties and other parameters to achieve the desired clinical efficacious candidate.
Pharmacokinetic studies in Aurigene are carried out to assess the potency of the drug compound by examining the parameters on elimination, half-lives, and ADME properties and help scientists to design safer pre clinical and clinical trials.
The standard pharmacokinetic process involves characterizing the potential drug by studying the ADME parameters. Depending upon the single or repeated dose the blood and urine samples are analyzed to determine exposure, dose levels, and preclinical testing.
Pharmacokinetic studies in animals involve validating the necessary parameters on ADME along with clearance studies, half-life, bio availability, volume of distribution, and protein drug interactions.
Pharmacokinetic study validates and ensures the safety and efficacy of drugs during pre-clinical and clinical trials by analyzing the ADME properties. It also provides data regarding drug-drug interactions and the disposition of a drug.
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October 24th-26th, 2023 | Barcelona, Spain
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