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In vivo Pharmacokinetics

In vivo Pharmacokinetics

We provide in vivo pharmacokinetic studies using wide range of administration routes.

Our pharmacokinetic (PK) studies in rats, mice and dogs help in understanding the characteristics of New Chemical entities (NCEs). Our PK studies are highly efficient in predicting the exposure while determining the dosage levels and frequencies for testing in preclinical in vivo animal disease efficacy models. We conduct PK studies for small and large molecules at our state-of-the-art laboratories and vivarium. Our DMPK scientists help understand the drug's AUC, clearance, half-life, the volume of distribution, Cmax, and Cmin in the body over time.

Industry’s leading CRO for Pharmacokinetic Studies A variety of surgical animal PK models Track record of delivering 200+ GLP studies GLP accredited bioanalysis labs for PK studiesNon-GLP bioanalysis facilities for PK studiesA wide range of administration routes

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PK in Rodents (Rats/ mice)

  • Single or Multiple dose
  • Discrete or Cassette
  • Micro sampling
  • Cross-over or Non-cross-over design
  • Dose escalation studies
  • Food effect, Gender effect

Surgical Models (Cannulations)

  • Single or double Jugular vein
  • Tail vein
  • Duodenum
  • Bile duct
  • Femoral vein

PK in Other Matrices (Rodents)

  • Issue distribution
  • Brain penetration
  • PK in CSF, Spinal cord, Sciatic nerve
  • Testes PK
  • Excretion studies

PK in Beagle Dogs

  • Single or multiple dose PK
  • Non-terminal studies

Route of Administration

  • Oral
  • Intravenous (IV)
  • Intramuscular (IM)
  • Subcutaneous (SC)
  • Intraperitoneal (IP)
  • Dermal

Why Aurigene Pharmaceutical Services?

Variety of surgical animal PK models

Track record of delivering 200+ GLP studies

GLP accredited bioanalysis labs for PK studies

Non-GLP bioanalysis facilities for PK studies

A wide range of administration routes

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Frequently asked questions

Why is pharmacokinetics important in drug discovery?

The characteristic study of pharmacokinetics of drugs in drug development is crucial to ensure its safety and efficacy along with optimizing its ADME properties and other parameters to achieve the desired clinical efficacious candidate.

What is the purpose of pharmacokinetic studies in Aurigene?

Pharmacokinetic studies in Aurigene are carried out to assess the potency of the drug compound by examining the parameters on elimination, half-lives, and ADME properties and help scientists to design safer pre clinical and clinical trials.

What is the process followed during pharmacokinetic studies in Aurigene?

The standard pharmacokinetic process involves characterizing the potential drug by studying the ADME parameters. Depending upon the single or repeated dose the blood and urine samples are analyzed to determine exposure, dose levels, and preclinical testing.

What are the parameters considered during pharmacokinetic studies in Aurigene?

Pharmacokinetic studies in animals involve validating the necessary parameters on ADME along with clearance studies, half-life, bio availability, volume of distribution, and protein drug interactions.

What are the benefits of pharmacokinetic studies?

Pharmacokinetic study validates and ensures the safety and efficacy of drugs during pre-clinical and clinical trials by analyzing the ADME properties. It also provides data regarding drug-drug interactions and the disposition of a drug.

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