We have the capability for designing and executing mid-size libraries in a remarkably shorter time frame, helping in quick screening for desired properties. Our large and selective in-house collection of acids, aldehydes, amines, phenols, boronic acids and heterocyclic halides are carefully selected to be compatible with most of the drug discovery concepts. We have capacity and experience to generate structurally diverse scaffolds in gram scale and to carry out their rapid diversifications using 1-3 step transformations with reactions like amide couplings, mitsunobu reactions, transition metal-mediated C-C and C-N bond-forming reactions, reductive aminations, click Chemistry etc.
Two decades of experience
Quick access to inventory
Fast turnaround time
Quick initiation of small libraries and scaffold synthesis
Design and synthesis of partial PROTAC libraries
FEBRUARY 05, 2021
Route Scouting is an essential step in the chemical development process for the manufacturing of a drug substance. When the compound passes the preclinical stage and reaches the development phase, the route of synthesis used in the drug discovery phase may not be feasible or be the optimum route of synthesis for large scale manufacturing.Process research scientis...Read More
The pharma industry is evolving and a demand for integrated CDMOs, which can help accelerating innovations, is part of the evolution....Read More
We are always looking for ways to enhance the sustainability of our products and services. Our team successfully developed a scalable manufacturing process for the API product of one of our Biotech clients using eco-friendly manufacturing technologies. Read the case study to learn more....Read More
Montmorillonite K-10 mediated green and one-pot synthesis of 2-substituted quinolines has been accomplished via a 3-component reaction of aniline, aldehydes and ethyl 3,3- diethoxypropionate in the presence of air oxygen in water. The crystal structure analysis and H-bonding patterns of one compound prepared are presented. ...Read More
Scalable alternate end-game strategies for the synthesis of the anti-COVID drug molecule Nirmatrelvir (1,PF-07321332) have been described. The first involves a direct synthesis of 1 via amidation of the carboxylic acid 7 (suitably activated as a mixed anhydride with either pivaloyl chloride or T3P) with the ...Read More
Mutations in MEK1/2 have been described as a resistance mechanism to BRAF/MEK inhibitor treatment. We report the discovery of a novel ATP-competitive MEK1/2 inhibitor with efficacy in wildtype (WT) and mutant MEK12 models. Starting from a HTS hit, we obtained selective, cellularly active ...Read More
Synthesis of the anti-covid therapeutic Nirmatrelvir by using flow chemistry to enhance efficiency of amide to nitrile conversion in a functionally and Stereochemically Embellished environment. ...Read More
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