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Custom Library Synthesis Services Custom Library Synthesis Services

Custom Library Synthesis Services

Aurigene provides services to rapidly synthesize focused, mid-size compound libraries with high purities, using wide range of in-house available building blocks.

We have the capability for designing and executing mid-size libraries in a remarkably shorter time frame, helping in quick screening for desired properties. Our large and selective in-house collection of acids, aldehydes, amines, phenols, boronic acids and heterocyclic halides are carefully selected to be compatible with most of the drug discovery concepts. We have capacity and experience to generate structurally diverse scaffolds in gram scale and to carry out their rapid diversifications using 1-3 step transformations with reactions like amide couplings, mitsunobu reactions, transition metal-mediated C-C and C-N bond-forming reactions, reductive aminations, click Chemistry etc.

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Custom Library Synthesis by Utilizing Wide Range of Chemistry Principles

  • Standard transformations like amidations, reductive aminations, alkylations, C-C, C-O and C-N bond formations etc.
  • Heterocyclic chemistry including the synthesis of almost any 5 or 6 membered ring analogues.
  • All commonly used protection and deprotection strategies, customized for acid-mediated, neutral, or base-mediated post-library works.
  • Routine transition metal-mediated reactions including Suzuki, Stille, Heck and many more have been executed in focused libraries.

Work Flow

Custom library synthesis workflow

Why Aurigene Pharmaceutical Services?

Two decades of experience

Quick access to inventory

Fast turnaround time

Quick initiation of small libraries and scaffold synthesis

Parallel synthesis

Design and synthesis of partial PROTAC libraries

Virtual Tour

Importance of Route Scouting in Chemical Development

Importance of Route Scouting in Chemical Development

Route Scouting is an essential step in the chemical development process for the manufacturing of a drug substance. When the compound passes the preclinical stage and reaches the development phase, the route of synthesis used in the drug discovery phase may not be feasible or be the optimum route of synthesis for large scale manufacturing.Process research scientis...

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Technology meets sustainability - How a complex API development process goes green

We are always looking for ways to enhance the sustainability of our products and services. Our team successfully developed a scalable manufacturing process for the API product of one of our Biotech clients using eco-friendly manufacturing technologies. Read the case study to learn more....

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Construction of a quinoline ring via a 3-component reaction in water: crystal structure analysis and H-bonding patterns of a 2-aryl quinoline


Montmorillonite K-10 mediated green and one-pot synthesis of 2-substituted quinolines has been accomplished via a 3-component reaction of aniline, aldehydes and ethyl 3,3- diethoxypropionate in the presence of air oxygen in water. The crystal structure analysis and H-bonding patterns of one compound prepared are presented. ...

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