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Custom Library Synthesis

Custom Library Synthesis

Aurigene provides services to rapidly synthesize focused, mid-size compound libraries with high purities, using wide range of in-house available building blocks.

We have the capability for designing and executing mid-size libraries in a remarkably shorter time frame, helping in quick screening for desired properties. Our large and selective in-house collection of acids, aldehydes, amines, phenols, boronic acids and heterocyclic halides are carefully selected to be compatible with most of the drug discovery concepts. We have capacity and experience to generate structurally diverse scaffolds in gram scale and to carry out their rapid diversifications using 1-3 step transformations with reactions like amide couplings, mitsunobu reactions, transition metal-mediated C-C and C-N bond-forming reactions, reductive aminations, click Chemistry etc.

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Custom Library Synthesis by Utilizing Wide Range of Chemistry Principles

  • Standard transformations like amidations, reductive aminations, alkylations, C-C, C-O and C-N bond formations etc.
  • Heterocyclic chemistry including the synthesis of almost any 5 or 6 membered ring analogues.
  • All commonly used protection and deprotection strategies, customized for acid-mediated, neutral, or base-mediated post-library works.
  • Routine transition metal-mediated reactions including Suzuki, Stille, Heck and many more have been executed in focused libraries.

Work Flow

Custom Library Synthesis

Why Aurigene Pharmaceutical Services?

Two decades of experience

Quick access to inventory

Fast turnaround time

Quick initiation of small libraries and scaffold synthesis

Parallel synthesis

Design and synthesis of partial PROTAC libraries

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