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In vitro ADME Services

In vitro ADME Services

In vitro ADME assays catering to every stage of drug discovery; standalone studies and customized assays.

We have more than 16 years of experience in ADME drug discovey services. We have validated ADME assays in place, amenable to customized study design as per customer requirement. Our expert team of scientists cater to the ADME requirements with unparalleled troubleshooting abilities. We have experience in handling small molecules, therapeutic peptides and complex molecules.

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Physiochemical Properties

Solubility and chemical stability at different pH, SIF and SGF

Solubility: Kinetic, thermodynamic, HT Log D

Permeability

Caco-2 Bi-directional permeability, Efflux ratio MDCK, MDCK-LE, MDCK-MDR1, MDCK-BCRP permeability PAMPA

Distribution

Plasma Protein, in vitro Tissue binding

Blood to plasma partition

Brain to plasma partition

Metabolism

Microsomal Clearance, S9, Phase I/Phase II, Hepatocyte Clearance

Plasma/ Whole Blood Stability CYP Phenotyping

Drug-Drug Interactions

CYP Inhibition, CYP TDI, kobs

CYP Induction

P-gp and BCRP Inhibition & Substrate Identification

Why Aurigene Pharmaceutical Services?

Quick turnaround time: In vitro Assays: 5 working days

High throughput (96-well plate) assays

Unidirectional and bidirectional permeability

Highly-experienced and expert team of scientists

Virtual Tour

 

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