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In vitro ADME Services In vitro ADME Services

In vitro ADME Services

In vitro ADME assays catering to every stage of drug discovery; standalone studies and customized assays.

We have more than 16 years of experience in ADME drug discovey services. We have validated ADME assays in place, amenable to customized study design as per customer requirement. Our expert team of scientists cater to the ADME requirements with unparalleled troubleshooting abilities. We have experience in handling small molecules, therapeutic peptides and complex molecules.

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Physiochemical Properties

Solubility and chemical stability at different pH, SIF and SGF

Solubility: Kinetic, thermodynamic, HT Log D


Caco-2 Bi-directional permeability, Efflux ratio MDCK, MDCK-LE, MDCK-MDR1, MDCK-BCRP permeability PAMPA


Plasma Protein, in vitro Tissue binding

Blood to plasma partition

Brain to plasma partition


Microsomal Clearance, S9, Phase I/Phase II, Hepatocyte Clearance

Plasma/ Whole Blood Stability CYP Phenotyping

Drug-Drug Interactions

CYP Inhibition, CYP TDI, kobs

CYP Induction

P-gp and BCRP Inhibition & Substrate Identification

Why Aurigene Pharmaceutical Services?

Quick turnaround time: In vitro Assays: 5 working days

High throughput (96-well plate) assays

Unidirectional and bidirectional permeability

Highly-experienced and expert team of scientists

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Neoantigen Specific T cells For Cancer Immunotherapy

Neoantigen Specific T cells For Cancer Immunotherapy

An effective anti-tumor immune response in human is marked by presence of T cells reactive against neoantigens. Neoantigens are HLA-bound unique peptides arise from tumor-specific somatic mutations. Neoantigens are highly immunogenic because they are not present in normal tissues and hence bypass central thymic tolerance. The success of immune checkpoint blockade...

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Accelerating Drug Discovery Through Innovative Partnerships

Genomics plays a vital role in identifying which gene is associated with a specific disease. A gene called CNOT1 is for example known for it's effect on brain development and for impairing memory and learning. Despite the great promise genomics provides in understanding the disease, genes are not the best drug targets....

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Physiochemical Characterization Services

Backed by our strong chemistry, we enable “Finger-print” protein structure and functional characterization for proteins from naked proteins to hyperglycosylated or derivatized proteins. ...

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Developing a methodology for In situ perfusion based combined tissue distribution and toxicity evaluation study

Challenges: Several repeated in house validation studies were performed to optimize the suitable perfusate (liquid medium intended to pass through the heart), perfusate volume and perfusion rate to ensure complete perfusion of animal subjects (parameters weren’t adjustable) Challenges were encountered in adjusting the perfusion volume and rate vis-à-vis ensuri...

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Synthesis of 2-hydroxy-3-alkyl-2-phenyl-2,3- dihydroquinazolin-4(1H)-one via molybdenum hexacarbonyl mediated CO gas- and ligand free carbonylative reactions


Carbon monoxide gas and ligand-free conditions were developed for the synthesis of 2-hydroxy-3-alkyl-2-phenyl-2,3-dihydroquinazolin4(1H)-one via catalytic carbonylation with molybdenum hexacarbonyl as an efficient carbonylating agent for the three-component reaction of isatoic anhydride, amine, iodobenzene. Mo(CO)6 is a solid carbon monoxide source. The quinazoli...

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