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Transforming peptide macrocyclization From low yields to scalable succes
Aurigene transformed a low-yielding peptide macrocyclization process by optimizing the coupling reagent, addition parameters, and impurity control — lifting conversion from 10-15% to 60-65% with >99% HPLC purity. The reproducible SPPS-to-cyclization workflow was successfully scaled to deliver a cGMP batch of cyclic peptide.
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