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End-to-End Rebuild of a Complex Bicyclic Peptide Synthesis
Aurigene rebuilt a complex bicyclic peptide synthesis end-to-end — solving aggregation, dimeric impurities, unnatural amino acid sourcing, and purification bottlenecks in a single program. The optimized process delivered a threefold yield improvement, simplified manufacturing, and enabled scale-up from 3 kg non-GMP supplies to 9 kg cGMP manufacturing, with a 2nd-generation process already underway.
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