Cost-effective tetramer peptide synthesis From costly purification to a kilo-scale LPPS proces

Aurigene developed a cost-effective LPPS (Liquid Phase Peptide Synthesis) route for a tetramer peptide by eliminating expensive RP-HPLC, ion exchange, and lyophilization steps while controlling racemization of unnatural basic amino acids through an orthogonal protection strategy and optimized coupling protocols. The commercially viable alternative route delivered >97% HPLC purity at multi-kilo scale, meeting all predefined specifications and driving significant cost savings for the customer.