Aurigene Pharmaceutical Services offers endotoxin LPS (Lipopolysaccharides) induced paw inflammation model using cell walls of gram-negative bacteria. Our study is designed to release various cytokines, when gram-negative bacteria is injected into mice/rat. LPS induced paw inflammation model can be used to determine the functional activity of cytokine modulation.
Study animals are grouped based on body weight and test compounds are administered prior to LPS challenge at a designated time depending upon the pharmacokinetics. Paw volume will be measured using plethysmometer before and after sub planter LPS injection at regular intervals. Optionally Tissue/Serum cytokines will be evaluated using ELISA kits and plasma test compounds levels will be determined for PK/PD studies.
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