Aurigene Pharmaceutical Services provides pharma and biotech companies access to a wide range of discovery and CDMO custom peptide synthesis services, such as:
-
Solid phase
synthesis 
Solution
phase synthesis
Hybrid
peptide synthesis
Our dedicated team of experts have a track record of handling peptides ranging from simple linear peptides to polypeptides synthesis and its very complex forms from milligram to multi-gram quantities for your discovery and developmental research needs. The portfolio of peptides includes complex peptides ranging from simple side chain modification, derivatized peptides to conformationally constrained peptides i.e. disulfide bridged peptides, stapled peptides, lactam bridged peptides & head to tail cyclisations. In addition, we can offer the synthesis of fluorescent labeled peptides, linkers, cystine rich peptides and peptidomimetic chemistry.
Aurigene Pharmaceutical Services offers state-of-the-art microwave synthesis, it enables high throughput synthesis of difficult to do peptide chemistry (e.g. synthesis of peptides with hindered and N-alkylated amino acids) and makes it possible to perform cycle times of 4-minutes while reducing the required amount of solvent by 90 %.
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Analytical infrastructure and purification technologies
- CEM automated microwave peptide synthesizer
- Analytical HPLCs
- Flash chromatography
- Reverse phase purification
- Ion exchange chromatography
- Salt exchange technologies
- Preparative HPLC lyophilizer
- LC-MS
Why Aurigene Pharmaceutical Services for Peptide services?
- Seamless support from discovery to development
- Value addition to your discovery projects through peptide design for potency, ADME and PK optimization for peptides
- Long and branched chain peptide synthesis. (i.e. upto 70 AA)
- Route scouting with process development and scaleup on multi-gram scale for all types of peptides
- Synthesis of conformationally constrained peptides i.e. Lactam, Disulfide bridging, head to tail cyclisation’s etc.
- Impurity profiling and characterization based on spectral methods
Aurigene Pharmaceutical Services is
a leading CDMO/CRO
that provides contract research and manufacturing services
FAQ
APSL has expertise in development and manufacturing of peptides via solid phase peptide synthesis (SPPS) and liquid phase peptide synthesis (LPPS) procedures.
The strategies involved are
- Convergent solid phase peptide synthesis where to fragments can be made separately and couple to make the final peptide
- Hybrid phase peptide synthesis which involves the combination of SPPS & LPPS methods. Our laboratories are equipped with manual and automated (CS Bio) peptide synthesizers to support the peptide synthesis as per the requirement.
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Other Services
- Custom Carbohydrate Synthesis
- Custom Library Synthesis
- Early Phase Development and Kilo Lab Facility
- Medicinal Chemistry Services
- Methoxy PEGs
- Oligonucleotide Synthesis Services
- Pharmaceutical Analytical services
- PROTAC Synthesis & Screening for Targeted Protein Degradation
- Solid Phase Peptide Synthesis Services
- Synthetic Chemistry Services
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