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Custom Peptide Synthesis  

Aurigene Pharmaceutical Services provides pharma and biotech companies access to a wide range of  discovery and CDMO custom peptide synthesis services, such as:

Our dedicated team of experts have a track record of handling peptides ranging from simple linear peptides to polypeptides synthesis and its very complex forms from milligram to multi-gram quantities for your discovery and developmental research needs. The portfolio of peptides includes complex peptides ranging from simple side chain modification, derivatized peptides to conformationally constrained peptides i.e. disulfide bridged peptides, stapled peptides, lactam bridged peptides & head to tail cyclisations. In addition, we can offer the synthesis of fluorescent labeled peptides, linkers, cystine rich peptides and peptidomimetic chemistry.

Aurigene Pharmaceutical Services offers state-of-the-art microwave synthesis, it enables high throughput synthesis of difficult to do peptide chemistry (e.g. synthesis of peptides with hindered and N-alkylated amino acids) and makes it possible to perform cycle times of 4-minutes while reducing the required amount of solvent by 90 %.

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Analytical infrastructure and purification technologies

  • CEM automated microwave peptide synthesizer
  • Analytical HPLCs
  • Flash chromatography
  • Reverse phase purification
  • Ion exchange chromatography
  • Salt exchange technologies
  • Preparative HPLC lyophilizer
  • LC-MS

Why Aurigene Pharmaceutical Services for Peptide services?

  • Seamless support from discovery to development
  • Value addition to your discovery projects through peptide design for potency, ADME and PK optimization for peptides
  • Long and branched chain peptide synthesis. (i.e. upto 70 AA)
  • Route scouting with process development and scaleup on multi-gram scale for all types of peptides
  • Synthesis of conformationally constrained peptides i.e. Lactam, Disulfide bridging, head to tail cyclisation’s etc.
  • Impurity profiling and characterization based on spectral methods

Aurigene Pharmaceutical Services is

a leading CDMO/CRO

that provides contract research and manufacturing services


There are three major synthesis routes for peptides, solid phase peptide synthesis (SPPS), solution/liquid phase peptide synthesis (LPPS) and hybrid phase peptide synthesis. Hybrid phase peptide synthesis is a combination of solid and liquid peptide synthesis methods.

Microwave assisted peptide synthesis is one of the most efficient and environmentally friendly method, it enables high throughput synthesis of difficult to make peptides and reduces cycle times to 4 minutes while minimizing the required amount of solvent by 90%.

Peptide synthesis depends on the required sequence length, complexity, purity and quantity of the peptide, it usually ranges from few days for a peptide to few weeks depending on these variables.

APSL has expertise in development and manufacturing of peptides via solid phase peptide synthesis (SPPS) and liquid phase peptide synthesis (LPPS) procedures.

The strategies involved are

  • Convergent solid phase peptide synthesis where to fragments can be made separately and couple to make the final peptide
  • Hybrid phase peptide synthesis which involves the combination of SPPS & LPPS methods. Our laboratories are equipped with manual and automated (CS Bio) peptide synthesizers to support the peptide synthesis as per the requirement.

Depending on the requirements, short and longer peptides can be synthesized between 5mer-50mer. SPPS approach is preferable to generate longer peptides Ex: 50 mer (with 50 amino acids).

Long chain peptides can be preferably synthesized following Solid Phase Peptide Synthesis (SPPS) procedures. Depending on the length and complexity of the peptide convergent or hybrid approaches can be adopted.

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