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Genotoxicity usually referred as adverse effects of a chemical on genetic material via any of a variety of mechanisms, including mutation. Genotoxicity testing is very crucial to perform to determine potential carcinogenic/mutagenic compounds that can cause genetic alterations in somatic or germ cells, and this information is used in regulatory decision-making. Mutagenicity (gene mutation and structural and numerical chromosomal alterations) is one of six basic testing areas that have been adopted by the Organization for Economic Co-operation and Development (OECD, 2011) as the minimum required to screen high-production volume chemicals in commerce for toxicity.

We provide a combination of tests to assess three major end-points of genetic damage associated with human disease: a) gene mutation (i.e. point mutations or deletions/insertions that affect single or blocks of genes) b) clastogenicity (i.e. structural chromosome changes); and c) aneuploidy (i.e. the occurrence of one or more extra or missing chromosomes, leading to an unbalanced chromosome complement).

  • Bacterial Reverse Mutation Test (OECD 471)
  • In vitro Chromosomal Aberration Test using human Blood Lymphocytes (OECD 473)
  • In vitro Micronucleus Test using human Blood Lymphocytes (OECD 487)
  • Mammalian Cell Gene Mutation Assay (OECD 490)
  • In vivo Micronucleus Test in Rats/Mice (OECD 474)

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