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Aurigene Pharmaceutical Services has two decades of experience in working with global clients in custom library synthesis of compounds and generating small to medium-sized custom libraries of target compounds. Our knowledge in generating a large number of target molecules in a remarkably shorter time frame enables quick biological screenings for affinities. With the target properties in mind, we deliver target molecules, by applying our extensive knowledge in drug discovery and in optimizing various NCEs, improved physicochemical properties, Pharmacokinetic (PK) properties and/or often for circumventing toxicology related concerns at different stages of discovery. This approach has always been pivotal in the design of 25-100 compound focussed libraries – customized to avoid the common pitfalls in drug discovery processes and to enhance the chance of hit identification or optimization with improved properties.

Our expertise in custom library synthesis of small to medium-sized, customized libraries utilizes a wide range of chemistry including:

  • Standard transformations like amidations, reductive aminations, alkylation’s, C-C, C-O and C-N bond formations etc.
  • Heterocyclic chemistry including the synthesis of almost any 5 or 6 membered ring analogues
  • All commonly used protection and deprotection strategies, customized for acid-mediated, neutral or base-mediated post-library works
  • Routine transition metal-mediated reactions including Suzuki, Stille, Heck and many more have been executed in focussed libraries
  • RP and chiral purification of synthesized targets to deliver compound libraries with high purities

Our large and selective in-house collection of acids, aldehydes, amines, phenols, boronic acids and heterocyclic halides are carefully selected to be compatible with most of the drug discovery concepts, where we focus on a high-performance library design that can exponentially enhance the success rate of a discovery program.

Aurigene Pharmaceutical Services is

a leading CRO/CDMO

that provides contract research and manufacturing services

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