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Custom Carbohydrate Synthesis

Aurigene Pharmaceutical Services has expertise in handling custom carbohydrate synthesis chemistry and has a track record of multiple projects for global clients. We possess in-depth understanding on selective protection and deprotection strategies, experience in handling moisture sensitive glycosylations,  triflates, azide transfer and oxidations. We are also experienced in the use of glycosyl donors like SMe, STolyl, SEt, Trichloroacetimidates and Sulphoxides. With our capacity for complex carbohydrate synthesis ranging from lab to pilot plant and commercial scale, we are also able to provide gram to kilogram quantities for the clinical development of NCEs.

Our capability also includes Ion exchange and gel permeation chromatography techniques along with expertise in downstream purification and isolation of water-soluble intermediates makes it possible to apply the ideal purification process.

We offer custom carbohydrate synthesis services for discovery, development and manufacturing stages:
 

  • Complex multi-step carbohydrates involving linear and convergent synthesis
  • Complex pentasaccharides
  • Monosaccharides
  • Polysaccharides
  • Iminosugars and Carbocyclic sugars
  • Glycopeptides
  • Thioglycosides Thiosugars
  • Nucleosides
  • Nucleosides containing ribose, deoxy ribose, fluorine and methyl sugars
  • Nucleotides