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Aurigene Pharmaceutical Services offers Zebrafish research (Danio rerio) models for drug discovery studies and screening of chemical compounds. Zebra fish models provide cost-effectiveness, faster turnaround times, and ease of genetic modifications, Zebrafish whole-animal models help get insights into compound efficacy, toxicity, and distribution at an early exploratory stage of drug discovery facilitating decision-making and earlyattrition. We have experience developing various Zebrafish models of CNS, immune system, genetic and metabolic disorders, and musculoskeletal diseases. We also provide exploratory pharmacology and toxicology services for compound libraries. We have the know-how of creating mutant lines using gene editing and silencing technologies which is leveraged for the generation of customized Zebrafish models. Chemical and diet-induced models are generated and validated using standardcompounds. As per study requirements, our teams can carry out screenings at embryo, larvae, and adult stages of Zebrafish.

Some established in vivo zebrafish disease models are:

  • Musculoskeletal Diseases
    • Amylotropic Lateral Sclerosis
    • Spinal Muscular Atrophy
    • Duchenne Muscular Dystrophy
  • Nervous System Diseases
    • Dominant Optic Atrophy
    • Fragile X Syndrome
    • Charcot-Marie-Tooth
    • Syndrome 2A
  • Immune System Disorders
    • X-linked agammaglobulinemia
  • Metabolic Disorders
    • Glutaric Aciduria Type I
    • Leigh’s Disease
  • Genetic Diseases
    • Lysosomal Storage Disorders Model
    • Gaucher’s Disease Model
    • Fabry Disease
    • Pompe Disease

Aurigene Pharmaceutical Services is

a leading CDMO/CRO

that provides contract research and manufacturing services

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