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In vivo Pharmacology Studies and Services In vivo Pharmacology Studies and Services

In vivo Pharmacology Studies and Services

We are an efficient partner for in vivo pharmacology services with our experience in multiple therapeutic areas, target specific models, and a team of highly competent scientists.

In vivo pharmacology is essential to evaluate the complex physiological effects of a drug in the living organism. Aurigene offers in vivo pharmacology studies to assess the effectiveness and early toxicity of small compounds and large molecules. Our in vivo pharmacology services are backed by an AAALAC-accredited vivarium.

Our expanding disease models include areas such as pain management, inflammation and auto immune diseases, metabolic disorders, oncology, and infectious diseases.

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Few therapeutic areas where we offer pharmacology discovery services are highlighted below:

Pain Models & Measurements

Aurigene has successfully collaborated with the world’s top pharmaceutical companies for pain drug discovery. Our expertise and experience allow us to offer an extensive portfolio of services supporting drug discovery and development. We match the industry needs in the domains of:

  • Acute and chronic inflammatory pain
  • Visceral pain
  • Arthritic pain
  • Neuropathic pain
Type​Animal ModelSpecies/ strain​Validation standard​
Acute ModelsAcetic acid induced writhingMale Swiss albino mice​Indomethacin/Tramadol​
Carrageenan-induced mechanical hyperalgesia ​Male Wistar rat​Celecoxib​
Complete Freund’s adjuvant (CFA) induced thermal hyperalgesiaMale Sprague Dawley rat​Indomethacin​
Arthritic Pain​CFA-induced mono arthritis pain​Male Sprague Dawley rat​Naproxen​
Monoidoacetate-induced osteoarthritis pai​Male Sprague Dawley rat ​Diclofenac​
Neuropathic PainPartial sciatic nerve ligation​Male Wistar rat​Gabapentin ​

Inflammation and Auto-immune Disorders

Our team of experts have developed in vivo models for autoimmune and inflammatory diseases. We offer inflammation animal models associated with:

  • Neurological diseases
  • Respiratory diseases
  • Arthritis
  • Skin diseases
  • Gastrointestinal diseases and
Type​Animal ModelSpecies/ strain​Validation standard​
Acute ModelsLPS -induced systemic inflammation (Plasma TNF-α)Female Wistar rat/ Male BALB/c miceRoflumilast / Theophylline
LPS- induced systemic inflammation (Plasma IL-17 )​Male C57BL/6 mice​​Digoxin​
LPS- induced paw edema​Female Wistar rat​Nimesulide
Carrageenan- induced paw edema​Male Wistar rat​​Celecoxib​
Acute Arthus reactionFemale C57BL mice​Kinase inhibitor
SCF- induced systemic histamine release modelFemale BALB/c mice​Anti C-KIT antibody
Mouse passive cutaneous anaphylaxis modelFemale C57BL/6 miceDexamethasone
TNF + Zvad-induced hypothermiaFemale C57BL miceKinase inhibitor
ArthritisCollagen-induced Arthritis (Prophylactic)​Female Lewis ratLeflunomide​
Collagen-induced Arthritis (Therapeutic)Female Lewis rat​Enbrel, Dexamethasone
Adjuvant-induced Arthritis (Prophylactic)​​​Female Lewis ratCelecoxib​
MIA- induced osteoarthritisFemale SD ratsDiclofenac , Diacerein​​​
Dermatitis & PsoriasisDNFB-induced contact dermatitis ​​Female CD1 mice​Leflunomide​ ​
Oxazolone-induced contact dermatitisMale SD ratDexamethasone
Imiquimod-induced psoriasis model​​Female BALB/c miceDexamethasone /Anti mouse IL-17 anti body
IL-23-induced dermatitis model​Female BALB/c miceTofacitinib/​
ColitisDextran sulphate sodium-induced colitisC57BL/6 mice​​​Cyclosporin​​
FibrosisUnilateral ureteral obstruction model​Male C57BL/6 miceNecrostatin-1​
Acne​Hamster ear sebaceous gland model​Female HamstersSpironolactone
Asthma​Ovalbumin/LPS-induced neutrophilic asthma model​Male C57BL/6 mice​Digoxin​
MS​MOG-induced EAE model in C57BL/6 ​Female C57BL/6 mice​Copaxone
Food allergy​Ovalbumin- induced GI allergy model​Female BALB/c miceAck-2 antibody
  • Gastrointestinal motility
Type​Animal ModelSpecies/ strain​Validation standard​
IleusPost-operative ileus modelMale C57BL/6 miceMosapride
Gastric emptyingPhenol red liquid meal test in mice ​Male BALB/c miceClonidine ​
Gastric emptying & intestinal motilityModified Charcoal meal test in mice​Male BALB/c miceAtropine sulphate, Clonidine

Metabolic Disorders (Diabetes, Obesity, and Atherosclerosis)

The team has vast experience in developing and conducting customized animal models for metabolic disorders.

Type​Strain-SpeciesActivity/test Model​​Validating/Standards​​
MD​ (Diabetes and Obesity)Mice and rats​OGTT, IPGTT, IVLTT, and Euglycemic clamp study​​Pioglitazone/Exenatide​
Swiss albino mice / Wistar rats/CD1 mice​​Acute food intake modulating activity ​Rimonabant/ PYY 3-36/Liraglutide
CD1 mice​3 days of administration of food intake and body weight lowering activity​PYY 3-36​
db/db mice​Blood glucose lowering and anti-dyslipidemic activityPioglitazone/ liraglutide
Zucker fa/fa ratsAnti-dyslipidemic activity and insulin-sensitizing activity​Fenofibrate/Pioglitazone​
ob/ob mice​Body weight lowering and insulin-sensitizing activity​​Metformin/Pioglitazone
C57BL/6 - DIO miceBody weight lowering activity​Rimonabant/PYY 3-36
CV (Atherosclerosis)LDLr -/-MicAnti-atherosclerotic activity​Fenofibrate​
Swiss albino miceLipid-lowering activityFenofibrate ​​
High-fat-fed Sprague Dawley ratsAcute lipid (TC, TG) lowering activity​Fenofibrate
Golden Syrian HamsterHDL elevating activity​Torcetrapib ​

Oncology Animal Model

Aurigene brings extensive experience in oncology drug discovery. We offer a large collection of tumor models for small and large molecule drug discovery including the CART-cell evaluation. We offer both syngeneic and xenograft tumor models and IVIS imaging-based studies with various biomarker using ELISA, Flow cytometry, RT-PCR, and western blot techniques.

Cancer type (Xenograft)​Cell lineMice ​​​
Ovarian cancerSKOV-03​NOD SCID mice
Acute myeloid leukemiaMOLM-13​​NOD SCID mice ​
Small intestine; DuodenumHUTU-80Nude mice​​​
Colon cancer​COLO 205Ncr nude mice
Colorectal AdenocarcinomaHT-29​​NOD SCID mice
Lung cancer, NSCLC​A549​​​Ncr nude mice
Small cell Lung cancer, SCLCSHP-77​​NOG mice
Ovarian adenocarcinoma​SKOV-3NOG mice
Prostrate cancerLNCaP​​NOG mice
Prostrate cancerVCaP​​NOG mice
Breast cancerMDA-MB-453​​NSG & NOD SCID mice
Breast cancerHCC-1954NSG & NOD SCID mice
Colorectal carcinomaHCT116NOD SCID mice
Colon cancerHCT-15NOD SCID mice
Cancer type (Syngenic)​Cell lineMice ​​​
Colon cancerCT-26BALB/c mice
Breast cancer4-T1​​BALB/c mice ​
B-cell lymphomaA-20BALB/c mice
Melanoma​B16-F10C57BL/6 mice

Miscellaneous models

  • Mouse/ rat whole blood and splenocyte assays with different stimulants (LPS, NECA) and evaluation of cytokines and biomarkers using flow cytometer.
  • Oxidative stress marker evaluation in rats administered with repeat intravenous iron formulation.
  • Evaluation of test compounds potential in modulating serum iron and hepcidin expression modulation in restricted iron diet fed rats.
  • Evaluation of test compounds potential in muscle regeneration in thermal injury mice model.
  • Anti-acne potential evaluation of test compounds in hamsters ear sebaceous gland model.
  • Evaluation of test compounds efficacy in mice post-operative ileus model.
  • Evaluation of test compounds efficacy in gastric emptying and intestinal motility in mice model.

Why Aurigene In vivo Pharmacology Studies Services?

Experience in submissions to the US FDA and DCGI

Highly qualified and experienced scientists

Capacity to handle more than 600 rodents at a given time

AAALAC-accredited vivarium

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Connect with our scientific experts for your drug discovery, development, and manufacturing needs

We understand that clear communication is essential to successful collaborations, and that's why we have a dedicated team that is always ready to help you. Whether you have questions about our services, want to discuss a potential partnership, or simply want to learn more about our company, we're here to help.

Our team of experts is dedicated to providing personalised solutions tailored to your unique needs. So, please don't hesitate to reach out to us. We look forward to hearing from you and helping you achieve your business goals.

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