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Our pharmacokinetic (PK) studies in rat, mice and dog, helps to understand the characteristics of a potential NCE and to predict the exposure and determine dose levels and frequencies for testing in preclinical in vivo animal disease efficacy models. We conduct PK studies for small and large molecules at our state-of-the-art laboratories and vivarium. Our DMPK scientists help understand the drugs AUC, clearance, half-life, volume of distribution, Cmax, and Cmin in the body over time.

Our Rat, Mice and Dog PK Studies Include:

  • Single, multiple, alternate and cassette dose studies
  • Dose linearity studies
  • Tissue Distribution studies
  • Brain penetration studies in rodents using cold compound
  • Broncho-alveolar lavage study
  • Drug-drug Interaction study
  • Fed/fasted state study
  • Blood-Brain Barrier & Cerebrospinal fluid (even from mice)
  • Excretion studies (rodent)
    • Bile
    • Urine
    • Feces
  • CYP P450 inhibition
  • Mechanistic studies
  • Toxicokinetic studies

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Animal species:

  • Rat
  • Mice
  • Beagle dog PK Studies

Route of administration:

  • Oral
  • Intravenous (IV)
  • Intramuscular (IM)
  • Subcutaneous (SC)
  • Intraperitoneal (IP)
  • Dermal

Surgical models

  • Single or double Jugular vein and Tail vein cannulations in rat
  • Duodenal and Jugular vein cannulation
  • Bile duct and Jugular vein cannulation
  • Femoral vein cannulation for IV infusion

Aurigene Pharmaceutical Services is

a leading CDMO/CRO

that provides contract research and manufacturing services

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